Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase

Pharmacology, Toxicology and Pharmaceutical Science

• Zika Virus 100%
• RNA Directed RNA Polymerase 100%
• Dengue Virus 33%
• Nonstructural Protein 5 25%
• Genomic RNA 8%
• Newborn Disease 8%
• Zika Fever 8%
• EC50 8%
• Flavivirus 8%

Keyphrases

• Virus RNA 100%
• Dengue Virus 33%
• NS5A 25%
• High-resolution Crystal Structure 8%
• RNA-dependent RNA Polymerase Activity 8%
• Synthetic Inhibitors 8%
• Allosteric Pocket 8%
• Antiviral Inhibitor 8%
• Antiviral Drug Development 8%
• Hinge Region 8%
• Allosteric Site 8%
• Viral RNA Genome 8%
• 50% Inhibitory Concentration 8%
• Flavivirus 8%
• Zika Virus Infection 8%
• Structure-based Design 8%
• RNA Polymerase Activity 8%