Projects per year
Personal profile
Biography
Dr Anna Barron is a Nanyang Assistant Professor of Neurobiology of Aging and Disease at the Lee Kong Chian School of Medicine (LKCMedicine), Nanyang Technological University and Assistant Director of the Brain Bank Singapore.
After obtaining her PhD in Neuroscience from The University of Western Australia, she carried out postdoctoral research in the US and Japan, first at the University of Southern California, followed by The University of Tokyo. Her interest in the use of molecular neuroimaging techniques led her to join the National Institute of Radiological Sciences, Japan, where she focused on the development and application of in vivo mitochondrial-targeted neuroimaging approaches. In 2017 she joined the faculty of LKCMedicine.
She has won a number of prestigious awards in recognition of her research, including the American-Australian Neurological Fellowship in 2009, the Japan Society for the Promotion for Science Invitational Postdoctoral Fellowship in 2010, the Alzheimer`s Association Imaging Consortium Fellowship in 2014 and the internationally competitive Alzheimer's Association Research Grant in 2018. In 2024 she was selected as an European Molecular Biology Organization (EMBO) Global Investigator.
Using advanced neuroimaging approaches, including PET and multiphoton fluorescence microscopy, in combination with cellular and molecular techniques, her team investigates how mitochondria contribute to brain health, aging and disease. Her research aims to uncover novel biomarkers and potential therapeutic avenues to promote healthy brain aging.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Cellular metabolism as a developmental regulator of microglial fate and function
Barron Anna (PI)
National Research Foundation Singapore
12/9/23 → 12/8/27
Project: Research project
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PET imaging of mitochondrial dysfunction in tauopathy
Barron Anna (PI)
1/1/18 → …
Project: Research project
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Evaluation of new generation translocator protein ligand efficacy in a mouse model of Alzheimer`s disease.
Barron Anna (PI)
Japan Society for the Promotion of Science
4/1/14 → 3/31/16
Project: Research project
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脳ステロイドホルモン合成の増強によるアルツハイマー病治療法の研究
Barron Anna (PI) & 川戸佳 佳. (CoPI)
Japan Society for the Promotion of Science
1/1/10 → 1/1/12
Project: Research project
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Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer’s disease
Asimakidou, E., Reynolds, R., Barron, A. M. & Hung Lo, C., Sept 2024, In: Neural Regeneration Research. 19, 9, p. 1869-1870 2 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Citations (Scopus) -
Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains
Huang, H. X., Inglese, P., Tang, J., Yagoubi, R., Correia, G. D. S., Horneffer-van der Sluis, V. M., Camuzeaux, S., Wu, V., Kopanitsa, M. V., Willumsen, N., Jackson, J. S., Barron, A. M., Saito, T., Saido, T. C., Gentlemen, S., Takats, Z. & Matthews, P. M., Jul 2024, In: Journal of Neurochemistry. 168, 7, p. 1193-1214 22 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
The mitochondrial translocator protein (TSPO) in Alzheimer's disease: Therapeutic and immunomodulatory functions
Fairley, L. H., Lai, K. O., Grimm, A., Eckert, A. & Barron, A. M., Sept 2024, In: Biochimie. 224, p. 120-131 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Citations (Scopus) -
Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration
Quick, J. D., Silva, C., Wong, J. H., Lim, K. L., Reynolds, R., Barron, A. M., Zeng, J. & Lo, C. H., Dec 2023, In: Journal of Neuroinflammation. 20, 1, 185.Research output: Contribution to journal › Review article › peer-review
Open Access48 Citations (Scopus) -
Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer’s disease
Fairley, L. H., Lai, K. O., Wong, J. H., Chong, W. J., Vincent, A. S., D’Agostino, G., Wu, X., Naik, R. R., Jayaraman, A., Langley, S. R., Ruedl, C. & Barron, A. M., Feb 21 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 8, e2209177120.Research output: Contribution to journal › Article › peer-review
Open Access48 Citations (Scopus)
Press/Media
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Study shows new way to spur brain immune cells to clear toxic waste linked to Alzheimer's disease
7/14/23
1 item of Media coverage
Press/Media: Research
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Clearing Toxic Waste Linked to Alzheimer’s – Study Finds Game-Changing Way To Boost Brain Immune Cells
5/9/23
1 item of Media coverage
Press/Media: Research