Projects per year
Personal profile
Biography
Nanyang Assistant Professor Franklin Zhong was awarded the Nanyang Assistant Professor and joined the faculty at the Lee Kong Chian School of Medicine in 2018. He completed his postdoctoral training at the Agency for Science, Technology and Research (A*STAR) in Singapore in the area of innate immunity and pathogen sensing. Asst Prof Zhong holds a PhD in Cancer Biology from Stanford University and a Bachelor’s in Natural Sciences from the University of Cambridge, UK.
Asst Prof Zhong’s research focuses on the inner workings of the human innate immune system in barrier tissues, such as the skin, that protects body’s internal organs from microbial infection. His latest work has led to the identification of new immune sensing pathways that regulate inflammation and cancer immune-surveillance, which could serve therapeutic targets in the treatment of infectious and auto-immune diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 1 Finished
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Characterizing the function of a novel immune sensor NLRP1 in skin infection and inflammation
Franklin Zhong (PI)
National Research Foundation Singapore
8/21/17 → 8/20/20
Project: Research project
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Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation
Gorse, L., Plessis, L., Wearne, S., Paradis, M., Pinilla, M., Chua, R., Lim, S. S., Pelluz, E., TOH, G. A., Mazars, R., Bomfim, C., Hervé, F., Lhaute, K., Réveillon, D., Suire, B., Ravon-Katossky, L., Benoist, T., Fromont, L., Péricat, D. & Neil Mertens, K. & 20 others, , 2025, (Accepted/In press) In: EMBO Molecular Medicine. 5.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural Basis of High-Precision Protein Ligation and Its Application
Chong, K. H. C., Liu, L., Chua, R., Chai, Y. T., Lu, Z., Liu, R., Tan, E. Y. J., Dong, J., Khoh, Y. H., Lin, J., Zhong, F. L., Lescar, J., Zheng, P. & Wu, B., Jan 15 2025, In: Journal of the American Chemical Society. 147, 2, p. 1604-1611 8 p.Research output: Contribution to journal › Article › peer-review
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Death by ribosome
Vind, A. C., Zhong, F. L. & Bekker-Jensen, S., 2024, (Accepted/In press) In: Trends in Cell Biology.Research output: Contribution to journal › Review article › peer-review
2 Citations (Scopus) -
Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome
Rozario, P., Pinilla, M., Gorse, L., Vind, A. C., Robinson, K. S., Toh, G. A., Firdaus, M. J., Martínez, J. F., Kerk, S. K., Lin, Z., Chambers, J. C., Bekker-Jense, S., Meunier, E. & Zhong, F., 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 2, e2309579121.Research output: Contribution to journal › Article › peer-review
Open Access13 Citations (Scopus) -
The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo
Vind, A. C., Wu, Z., Firdaus, M. J., Snieckute, G., Toh, G. A., Jessen, M., Martínez, J. F., Haahr, P., Andersen, T. L., Blasius, M., Koh, L. F., Maartensson, N. L., Common, J. E. A., Gyrd-Hansen, M., Zhong, F. L. & Bekker-Jensen, S., Dec 19 2024, In: Molecular Cell. 84, 24, p. 4774-4789.e9Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus)
Press/Media
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A new study reveals that we’ve been wrong about what causes sunburns
3/20/25
1 item of Media coverage
Press/Media: Research
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What’s the main cause behind sunburn? Scientists make startling discoveries
1/26/25
1 item of Media coverage
Press/Media: Research
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Main Cause of Solar Burns Identified: Key Insights Revealed
1/24/25
1 item of Media coverage
Press/Media: Research
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Scientists reveal surprising truth: DNA damage not the main culprit in sunburns
1/24/25
1 item of Media coverage
Press/Media: Research
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What’s the main cause behind sunburn? Scientists make startling discoveries
1/23/25
1 item of Media coverage
Press/Media: Research