Wu Bin

Education School of Biological Sciences, Nanyang Technological University, Singapore Ph.D. in Biochemistry, Biophysics and Structural Biology, 2006.07-2010.02 B.Sc. in Biological Sciences, 2002.07-2006.06 Research Experience Charles A. King Research Fellow, Harvard Medical School, 2010-present Advisor: Sun Hur Dissected the molecular mechanisms for viral RNA recognition and signaling by RIG-I/MDA5 and MAVS, an important innate immune signaling pathway related to multiple diseases. Investigated viral dsRNA recognition process of MDA5 by using techniques including biochemistry, molecular biology, X-ray crystallography and electron microscopy (Wu et al, Cell, 2013). This work is exclusively highlighted in Nature Review Immunology 2013. Established an in vitro reconstituted assay system to study MAVS signaling, which was applied to study related innate immune receptors and lead to the identification of RNA dependent filament formation as an important signaling mechanism in innate immunity (Peisley & Wu et al, Mol Cell, 2013) & (Peisley, Wu, et al, Nature, 2014). In addition, I also solved the MAVS filament structure (Wu et al, Mol Cell, 2014). Graduate Student, Nanyang Technological University, 2006-2010 Advisor: Curt A. Davey Using a combination of biochemical and biophysical tools, I characterized the molecular basis of therapeutic effects of Pt based anti-cancer drugs. Demonstrated how these drugs inhibited the dynamics of the basic functional units of our genome, the nucleosomes (Wu et al, Nature Chemical Biology, 2008). This work is also highlighted in Nature 2008. Additional work on biochemical and structural studies of nucleosomes with a variety of DNA sequences or modified DNA directly demonstrated the evidence of DNA sequence dependent nucleosome.