Harnessing CEACAM Biology: From Cells to Tissues

Understanding the mechanisms that control how cells interact with each other, and their environment, is fundamental to a whole host of processes, including cell adhesion and cell-cell communication. New tools are allowing us to now probe these mechanisms at the level of the individual molecules and to probe these mechanisms dynamically. In this study, we propose to use and adapt such tools to look at a model series of membrane-associated proteins involved in cell growth, adhesion, and activation. Insights from these studies will be important for understanding tumour development and cell death.