Understanding the role of the endoplasmic reticulum - plasma membrane contact sites in lipid transport

Outline of Final Research Achievements

The endoplasmic reticulum (ER), where the majority of membrane lipids are synthesized, extends throughout the cell and forms physical contacts with virtually all other cellular organelles, including the plasma membrane. Growing evidence suggests that lipid transfer proteins (LTPs) act at membrane contact sites and transport specific lipids from one membrane to another independent of membrane traffic. However, the molecular mechanisms that regulate the functions of LTPs are still largely elusive. In this study, we investigate how the functions of LTPs are regulated, focusing on ER-plasma membrane contact sites. Defects in cellular lipid homeostasis are linked to numerous human disorders, including neurodegenerative conditions, such as Alzheimer's disease and Parkinson's disease. Thus, our research not only provides insight into fundamental cell biology but also paves a way toward developing a novel therapeutic approach against neurodegeneration.