α-Amino Acetal: A Synthetic Intermediate for the Construction of Aza-Polycycles

Duan Yang Liu; Si Mao Zhu; Rui Qi Li; Jie Sheng Tian; Teck Peng Loh

doi:10.1021/acs.orglett.9b02240

α-Amino Acetal: A Synthetic Intermediate for the Construction of Aza-Polycycles

Duan Yang Liu, Si Mao Zhu, Rui Qi Li, Jie Sheng Tian^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

One-step construction of aza-polycyclic skeletons was realized through double cyclization of the oxocarbenium and carbocation intermediates generated from α-amino acetals, which were designed and synthesized by employing our α-amination protocol of aldehydes. A simple process, a broad substrate range, commercialized materials, and extensive applications demonstrated the generality and effectiveness of this method.

Original language	English
Pages (from-to)	6357-6360
Number of pages	4
Journal	Organic Letters
Volume	21
Issue number	16
DOIs	https://doi.org/10.1021/acs.orglett.9b02240
Publication status	Published - Aug 16 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 American Chemical Society.

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.9b02240

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abstract = "One-step construction of aza-polycyclic skeletons was realized through double cyclization of the oxocarbenium and carbocation intermediates generated from α-amino acetals, which were designed and synthesized by employing our α-amination protocol of aldehydes. A simple process, a broad substrate range, commercialized materials, and extensive applications demonstrated the generality and effectiveness of this method.",

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AU - Zhu, Si Mao

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AU - Tian, Jie Sheng

AU - Loh, Teck Peng

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N2 - One-step construction of aza-polycyclic skeletons was realized through double cyclization of the oxocarbenium and carbocation intermediates generated from α-amino acetals, which were designed and synthesized by employing our α-amination protocol of aldehydes. A simple process, a broad substrate range, commercialized materials, and extensive applications demonstrated the generality and effectiveness of this method.

AB - One-step construction of aza-polycyclic skeletons was realized through double cyclization of the oxocarbenium and carbocation intermediates generated from α-amino acetals, which were designed and synthesized by employing our α-amination protocol of aldehydes. A simple process, a broad substrate range, commercialized materials, and extensive applications demonstrated the generality and effectiveness of this method.

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α-Amino Acetal: A Synthetic Intermediate for the Construction of Aza-Polycycles

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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