β-Functionalization of carboxylic anhydrides with β-alkyl substituents through carbene Organocatalysis

Zhichao Jin; Shaojin Chen; Yuhuang Wang; Pengcheng Zheng; Song Yang; Yonggui Robin Chi

doi:10.1002/anie.201408604

β-Functionalization of carboxylic anhydrides with β-alkyl substituents through carbene Organocatalysis

Zhichao Jin^*, Shaojin Chen, Yuhuang Wang, Pengcheng Zheng, Song Yang, Yonggui Robin Chi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Abstract

The first NHC-catalyzed functionalization of carboxylic anhydrides is described. In this reaction, the b carbon behaves as a nucleophilic carbon and undergoes asymmetric reactions with electrophiles. Anhydrides with challenging balkyl substituents work effectively.

Original language	English
Pages (from-to)	13506-13509
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	53
Issue number	49
DOIs	https://doi.org/10.1002/anie.201408604
Publication status	Published - Oct 3 2014
Externally published	Yes

Bibliographical note

Publisher Copyright:
©2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

ASJC Scopus Subject Areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.201408604

Cite this

@article{32ab40acb78e4263b335c9a04c25c289,

title = "β-Functionalization of carboxylic anhydrides with β-alkyl substituents through carbene Organocatalysis",

abstract = "The first NHC-catalyzed functionalization of carboxylic anhydrides is described. In this reaction, the b carbon behaves as a nucleophilic carbon and undergoes asymmetric reactions with electrophiles. Anhydrides with challenging balkyl substituents work effectively.",

author = "Zhichao Jin and Shaojin Chen and Yuhuang Wang and Pengcheng Zheng and Song Yang and Chi, \{Yonggui Robin\}",

note = "Publisher Copyright: {\textcopyright}2014 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2014",

month = oct,

day = "3",

doi = "10.1002/anie.201408604",

language = "English",

volume = "53",

pages = "13506--13509",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "49",

}

TY - JOUR

T1 - β-Functionalization of carboxylic anhydrides with β-alkyl substituents through carbene Organocatalysis

AU - Jin, Zhichao

AU - Chen, Shaojin

AU - Wang, Yuhuang

AU - Zheng, Pengcheng

AU - Yang, Song

AU - Chi, Yonggui Robin

PY - 2014/10/3

Y1 - 2014/10/3

N2 - The first NHC-catalyzed functionalization of carboxylic anhydrides is described. In this reaction, the b carbon behaves as a nucleophilic carbon and undergoes asymmetric reactions with electrophiles. Anhydrides with challenging balkyl substituents work effectively.

AB - The first NHC-catalyzed functionalization of carboxylic anhydrides is described. In this reaction, the b carbon behaves as a nucleophilic carbon and undergoes asymmetric reactions with electrophiles. Anhydrides with challenging balkyl substituents work effectively.

UR - http://www.scopus.com/inward/record.url?scp=84915826414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84915826414&partnerID=8YFLogxK

U2 - 10.1002/anie.201408604

DO - 10.1002/anie.201408604

M3 - Article

C2 - 25284248

AN - SCOPUS:84915826414

SN - 1433-7851

VL - 53

SP - 13506

EP - 13509

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 49

ER -

β-Functionalization of carboxylic anhydrides with β-alkyl substituents through carbene Organocatalysis

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this