11.03 - Sodium and Potassium Complexes in Organic Synthesis

This review, the 4th iteration of the series covering on the synthetic application of organosodium and organopotassium chemistry with the first 3 volumes published in 1982, 1995 and 2007, discussed the latest development on chemistry of organosodium/potassium reagents in terms of their generation, reactivity, and applications in chemical synthesis. The structural elucidations of the exotic yet attractively reactive organosodium and potassium species allowed for design and implementation of their synthetic applications, especially deprotonative metalations. Employment of continuous flow technologies has expanded the synthetic scope in leveraging of organosodium/potassium reagents for development of novel molecular transformations, which are hitherto difficult to be practiced in conventional batch processes.