A cell apoptosis probe based on fluorogen with aggregation induced emission characteristics

Qinglian Hu; Meng Gao; Guangxue Feng; Xiaodong Chen; Bin Liu

doi:10.1021/am508838z

A cell apoptosis probe based on fluorogen with aggregation induced emission characteristics

Qinglian Hu, Meng Gao, Guangxue Feng, Xiaodong Chen, Bin Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

A fluorogen-based aggregation-induced emission zinc-dipicolylamine (AIE-ZnDPA) probe with aggregation-induced emission characteristics has been designed and synthesized to detect cell apoptosis. AIE-ZnDPA does not respond to healthy cells but selectively stains and lights up fluorescence in the membranes of early stage apoptotic cells as well as the nuclei of late stage apoptotic cells. Without zinc coordination, the precursor lipophilic AIE dipicolylamine (AIE-DPA) probe stains healthy cells and shows high affinity for lipid droplets (LDs).

Original language	English
Pages (from-to)	4875-4882
Number of pages	8
Journal	ACS Applied Materials and Interfaces
Volume	7
Issue number	8
DOIs	https://doi.org/10.1021/am508838z
Publication status	Published - Mar 4 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

ASJC Scopus Subject Areas

General Materials Science

Keywords

aggregation-induced emission
cell apoptosis
lipid droplet
zinc coordination

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10.1021/am508838z

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title = "A cell apoptosis probe based on fluorogen with aggregation induced emission characteristics",

abstract = "A fluorogen-based aggregation-induced emission zinc-dipicolylamine (AIE-ZnDPA) probe with aggregation-induced emission characteristics has been designed and synthesized to detect cell apoptosis. AIE-ZnDPA does not respond to healthy cells but selectively stains and lights up fluorescence in the membranes of early stage apoptotic cells as well as the nuclei of late stage apoptotic cells. Without zinc coordination, the precursor lipophilic AIE dipicolylamine (AIE-DPA) probe stains healthy cells and shows high affinity for lipid droplets (LDs).",

keywords = "aggregation-induced emission, cell apoptosis, lipid droplet, zinc coordination",

author = "Qinglian Hu and Meng Gao and Guangxue Feng and Xiaodong Chen and Bin Liu",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

month = mar,

day = "4",

doi = "10.1021/am508838z",

language = "English",

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TY - JOUR

T1 - A cell apoptosis probe based on fluorogen with aggregation induced emission characteristics

AU - Hu, Qinglian

AU - Gao, Meng

AU - Feng, Guangxue

AU - Chen, Xiaodong

AU - Liu, Bin

PY - 2015/3/4

Y1 - 2015/3/4

N2 - A fluorogen-based aggregation-induced emission zinc-dipicolylamine (AIE-ZnDPA) probe with aggregation-induced emission characteristics has been designed and synthesized to detect cell apoptosis. AIE-ZnDPA does not respond to healthy cells but selectively stains and lights up fluorescence in the membranes of early stage apoptotic cells as well as the nuclei of late stage apoptotic cells. Without zinc coordination, the precursor lipophilic AIE dipicolylamine (AIE-DPA) probe stains healthy cells and shows high affinity for lipid droplets (LDs).

AB - A fluorogen-based aggregation-induced emission zinc-dipicolylamine (AIE-ZnDPA) probe with aggregation-induced emission characteristics has been designed and synthesized to detect cell apoptosis. AIE-ZnDPA does not respond to healthy cells but selectively stains and lights up fluorescence in the membranes of early stage apoptotic cells as well as the nuclei of late stage apoptotic cells. Without zinc coordination, the precursor lipophilic AIE dipicolylamine (AIE-DPA) probe stains healthy cells and shows high affinity for lipid droplets (LDs).

KW - aggregation-induced emission

KW - cell apoptosis

KW - lipid droplet

KW - zinc coordination

UR - http://www.scopus.com/inward/record.url?scp=84924263538&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924263538&partnerID=8YFLogxK

U2 - 10.1021/am508838z

DO - 10.1021/am508838z

M3 - Article

C2 - 25671791

AN - SCOPUS:84924263538

SN - 1944-8244

VL - 7

SP - 4875

EP - 4882

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 8

ER -

A cell apoptosis probe based on fluorogen with aggregation induced emission characteristics

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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