A chemically mediated artificial neuron

Ting Wang; Ming Wang; Jianwu Wang; Le Yang; Xueyang Ren; Gang Song; Shisheng Chen; Yuehui Yuan; Ruiqing Liu; Liang Pan; Zheng Li; Wan Ru Leow; Yifei Luo; Shaobo Ji; Zequn Cui; Ke He; Feilong Zhang; Fengting Lv; Yuanyuan Tian; Kaiyu Cai; Bowen Yang; Jingyi Niu; Haochen Zou; Songrui Liu; Guoliang Xu; Xing Fan; Benhui Hu; Xian Jun Loh; Lianhui Wang; Xiaodong Chen

doi:10.1038/s41928-022-00803-0

A chemically mediated artificial neuron

Ting Wang, Ming Wang, Jianwu Wang, Le Yang, Xueyang Ren, Gang Song, Shisheng Chen, Yuehui Yuan, Ruiqing Liu, Liang Pan, Zheng Li, Wan Ru Leow, Yifei Luo, Shaobo Ji, Zequn Cui, Ke He, Feilong Zhang, Fengting Lv, Yuanyuan Tian, Kaiyu CaiBowen Yang, Jingyi Niu, Haochen Zou, Songrui Liu, Guoliang Xu, Xing Fan, Benhui Hu^*, Xian Jun Loh, Lianhui Wang, Xiaodong Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

118 Citations (Scopus)

Abstract

Brain–machine interfaces typically rely on electrophysiological signals to interpret and transmit neurological information. In biological systems, however, neurotransmitters are chemical-based interneuron messengers. This mismatch can potentially lead to incorrect interpretation of the transmitted neuron information. Here we report a chemically mediated artificial neuron that can receive and release the neurotransmitter dopamine. The artificial neuron detects dopamine using a carbon-based electrochemical sensor and then processes the sensory signals using a memristor with synaptic plasticity, before stimulating dopamine release through a heat-responsive hydrogel. The system responds to dopamine exocytosis from rat pheochromocytoma cells and also releases dopamine to activate pheochromocytoma cells, forming a chemical communication loop similar to interneurons. To illustrate the potential of this approach, we show that the artificial neuron can trigger the controllable movement of a mouse leg and robotic hand.

Original language	English
Pages (from-to)	586-595
Number of pages	10
Journal	Nature Electronics
Volume	5
Issue number	9
DOIs	https://doi.org/10.1038/s41928-022-00803-0
Publication status	Published - Sept 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Limited.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Instrumentation
Electrical and Electronic Engineering

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10.1038/s41928-022-00803-0

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title = "A chemically mediated artificial neuron",

abstract = "Brain–machine interfaces typically rely on electrophysiological signals to interpret and transmit neurological information. In biological systems, however, neurotransmitters are chemical-based interneuron messengers. This mismatch can potentially lead to incorrect interpretation of the transmitted neuron information. Here we report a chemically mediated artificial neuron that can receive and release the neurotransmitter dopamine. The artificial neuron detects dopamine using a carbon-based electrochemical sensor and then processes the sensory signals using a memristor with synaptic plasticity, before stimulating dopamine release through a heat-responsive hydrogel. The system responds to dopamine exocytosis from rat pheochromocytoma cells and also releases dopamine to activate pheochromocytoma cells, forming a chemical communication loop similar to interneurons. To illustrate the potential of this approach, we show that the artificial neuron can trigger the controllable movement of a mouse leg and robotic hand.",

author = "Ting Wang and Ming Wang and Jianwu Wang and Le Yang and Xueyang Ren and Gang Song and Shisheng Chen and Yuehui Yuan and Ruiqing Liu and Liang Pan and Zheng Li and Leow, {Wan Ru} and Yifei Luo and Shaobo Ji and Zequn Cui and Ke He and Feilong Zhang and Fengting Lv and Yuanyuan Tian and Kaiyu Cai and Bowen Yang and Jingyi Niu and Haochen Zou and Songrui Liu and Guoliang Xu and Xing Fan and Benhui Hu and Loh, {Xian Jun} and Lianhui Wang and Xiaodong Chen",

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month = sep,

doi = "10.1038/s41928-022-00803-0",

language = "English",

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Wang, T, Wang, M, Wang, J, Yang, L, Ren, X, Song, G, Chen, S, Yuan, Y, Liu, R, Pan, L, Li, Z, Leow, WR, Luo, Y, Ji, S, Cui, Z, He, K, Zhang, F, Lv, F, Tian, Y, Cai, K, Yang, B, Niu, J, Zou, H, Liu, S, Xu, G, Fan, X, Hu, B, Loh, XJ, Wang, L & Chen, X 2022, 'A chemically mediated artificial neuron', Nature Electronics, vol. 5, no. 9, pp. 586-595. https://doi.org/10.1038/s41928-022-00803-0

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AU - Wang, Jianwu

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AU - Yuan, Yuehui

AU - Liu, Ruiqing

AU - Pan, Liang

AU - Li, Zheng

AU - Leow, Wan Ru

AU - Luo, Yifei

AU - Ji, Shaobo

AU - Cui, Zequn

AU - He, Ke

AU - Zhang, Feilong

AU - Lv, Fengting

AU - Tian, Yuanyuan

AU - Cai, Kaiyu

AU - Yang, Bowen

AU - Niu, Jingyi

AU - Zou, Haochen

AU - Liu, Songrui

AU - Xu, Guoliang

AU - Fan, Xing

AU - Hu, Benhui

AU - Loh, Xian Jun

AU - Wang, Lianhui

AU - Chen, Xiaodong

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AB - Brain–machine interfaces typically rely on electrophysiological signals to interpret and transmit neurological information. In biological systems, however, neurotransmitters are chemical-based interneuron messengers. This mismatch can potentially lead to incorrect interpretation of the transmitted neuron information. Here we report a chemically mediated artificial neuron that can receive and release the neurotransmitter dopamine. The artificial neuron detects dopamine using a carbon-based electrochemical sensor and then processes the sensory signals using a memristor with synaptic plasticity, before stimulating dopamine release through a heat-responsive hydrogel. The system responds to dopamine exocytosis from rat pheochromocytoma cells and also releases dopamine to activate pheochromocytoma cells, forming a chemical communication loop similar to interneurons. To illustrate the potential of this approach, we show that the artificial neuron can trigger the controllable movement of a mouse leg and robotic hand.

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A chemically mediated artificial neuron

Abstract

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