TY - JOUR
T1 - A Deep Learning Approach for Accurate Discrimination Between Optic Disc Drusen and Papilledema on Fundus Photographs
AU - Sathianvichitr, Kanchalika
AU - Najjar, Raymond P.
AU - Zhiqun, Tang
AU - Fraser, J. Alexander
AU - Yau, Christine W.L.
AU - Girard, Michael J.A.
AU - Costello, Fiona
AU - Lin, Mung Y.
AU - Lagrèze, Wolf A.
AU - Vignal-Clermont, Catherine
AU - Fraser, Clare L.
AU - Hamann, Steffen
AU - Newman, Nancy J.
AU - Biousse, Valérie
AU - Milea, Dan
AU - Petzold, Axel
AU - Gohier, Philippe
AU - Miller, Neil R.
AU - Vanikieti, Kavin
AU - Milea, Leonard
AU - Carelli, Valerio
AU - Barboni, Piero
AU - La Morgia, Chiara
AU - Rougier, Marie Bénédicte
AU - Bénard-Séguin, Étienne
AU - Ambika, Selvakumar
AU - Fonseca, Pedro L.
AU - Wibroe, Elisabeth Arnberg
AU - Kuchlin, Sebastian
AU - Sanda, Nicolae
AU - Chiquet, Christophe
AU - Yang, Hui
AU - Chan, Carmen K.M.
AU - Cheung, Carol Y.
AU - Kilangalanga, Janvier Ngoy
AU - Nakamura, Makoto
AU - Fumio, Takano
AU - Jurkute, Neringa
AU - Yu-Wai-Man, Patrick
AU - Kho, Richard
AU - Jonas, Jost
AU - Dinkin, Marc Joshua
AU - Chen, John J.
AU - Sadun, Riccardo
AU - Hwang, Jeong Min
AU - Kim, Dong Hyun
AU - Yang, Hee Kyung
AU - Loo, Jing Liang
AU - Schmetterer, Leopold
AU - Lamoureux, Ecosse
AU - Aung, Tin
AU - Ting, Daniel
AU - Wong, Tien Yin
AU - Ming Foo, Reuben Chao
AU - Singhal, Shweta
AU - Lee Choon Tow, Sharon
AU - Vasseneix, Caroline
AU - Mejico, Luis J.
AU - Fard, Masoud Aghsaei
AU - Micieli, Jonathan A.
AU - Bikbov, Mukharram M.
N1 - Publisher Copyright:
© North American Neuro-Ophthalmology Society.
PY - 2024/12/1
Y1 - 2024/12/1
N2 - Background:Optic disc drusen (ODD) represent an important differential diagnosis of papilledema caused by intracranial hypertension, but their distinction may be difficult in clinical practice. The aim of this study was to train, validate, and test a dedicated deep learning system (DLS) for binary classification of ODD vs papilledema (including various subgroups within each category), on conventional mydriatic digital ocular fundus photographs collected in a large international multiethnic population.Methods:This retrospective study included 4,508 color fundus images in 2,180 patients from 30 neuro-ophthalmology centers (19 countries) participating in the Brain and Optic Nerve Study with Artificial Intelligence (BONSAI) Group. For training and internal validation, we used 857 ODD images and 3,230 papilledema images, in 1,959 patients. External testing was performed on an independent data set (221 patients), including 207 images with ODD (96 visible and 111 buried), provided by 3 centers of the Optic Disc Drusen Studies Consortium, and 214 images of papilledema (92 mild-to-moderate and 122 severe) from a previously validated study.Results:The DLS could accurately distinguish between all ODD and papilledema (all severities included): Area under the receiver operating characteristic curve (AUC) 0.97 (95% confidence interval [CI], 0.96-0.98), accuracy 90.5% (95% CI, 88.0%-92.9%), sensitivity 86.0% (95% CI, 82.1%-90.1%), and specificity 94.9% (95% CI, 92.3%-97.6%). The performance of the DLS remained high for discrimination of buried ODD from mild-to-moderate papilledema: AUC 0.93 (95% CI, 0.90-0.96), accuracy 84.2% (95% CI, 80.2%-88.6%), sensitivity 78.4% (95% CI, 72.2%-84.7%), and specificity 91.3% (95% CI, 87.0%-96.4%).Conclusions:A dedicated DLS can accurately distinguish between ODD and papilledema caused by intracranial hypertension, even when considering buried ODD vs mild-to-moderate papilledema.
AB - Background:Optic disc drusen (ODD) represent an important differential diagnosis of papilledema caused by intracranial hypertension, but their distinction may be difficult in clinical practice. The aim of this study was to train, validate, and test a dedicated deep learning system (DLS) for binary classification of ODD vs papilledema (including various subgroups within each category), on conventional mydriatic digital ocular fundus photographs collected in a large international multiethnic population.Methods:This retrospective study included 4,508 color fundus images in 2,180 patients from 30 neuro-ophthalmology centers (19 countries) participating in the Brain and Optic Nerve Study with Artificial Intelligence (BONSAI) Group. For training and internal validation, we used 857 ODD images and 3,230 papilledema images, in 1,959 patients. External testing was performed on an independent data set (221 patients), including 207 images with ODD (96 visible and 111 buried), provided by 3 centers of the Optic Disc Drusen Studies Consortium, and 214 images of papilledema (92 mild-to-moderate and 122 severe) from a previously validated study.Results:The DLS could accurately distinguish between all ODD and papilledema (all severities included): Area under the receiver operating characteristic curve (AUC) 0.97 (95% confidence interval [CI], 0.96-0.98), accuracy 90.5% (95% CI, 88.0%-92.9%), sensitivity 86.0% (95% CI, 82.1%-90.1%), and specificity 94.9% (95% CI, 92.3%-97.6%). The performance of the DLS remained high for discrimination of buried ODD from mild-to-moderate papilledema: AUC 0.93 (95% CI, 0.90-0.96), accuracy 84.2% (95% CI, 80.2%-88.6%), sensitivity 78.4% (95% CI, 72.2%-84.7%), and specificity 91.3% (95% CI, 87.0%-96.4%).Conclusions:A dedicated DLS can accurately distinguish between ODD and papilledema caused by intracranial hypertension, even when considering buried ODD vs mild-to-moderate papilledema.
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U2 - 10.1097/WNO.0000000000002223
DO - 10.1097/WNO.0000000000002223
M3 - Article
C2 - 39090774
AN - SCOPUS:85200744872
SN - 1070-8022
VL - 44
SP - 454
EP - 461
JO - Journal of Neuro-Ophthalmology
JF - Journal of Neuro-Ophthalmology
IS - 4
ER -