A divergent approach to apoptolidin and FD-891: Asymmetric preparation of a common intermediate

Shu Sin Chng; Jia Xu; Teck Peng Loh

doi:10.1016/S0040-4039(03)01173-0

A divergent approach to apoptolidin and FD-891: Asymmetric preparation of a common intermediate

Shu Sin Chng, Jia Xu, Teck Peng Loh^*

^*Corresponding author for this work

National University of Singapore

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Biologically active Apoptolidin and FD-891 have structural similarity in their macrocyclic cores. Asymmetric preparation of a common intermediate in the total synthesis of these two macrolides is presented. A modified Masuyama Sn-allylation was employed to control the relative stereochemistry in the synthesis of the intermediate.

Original language	English
Pages (from-to)	4997-5000
Number of pages	4
Journal	Tetrahedron Letters
Volume	44
Issue number	27
DOIs	https://doi.org/10.1016/S0040-4039(03)01173-0
Publication status	Published - Jun 30 2003
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

Apoptolidin
Divergent synthesis
FD-891

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10.1016/S0040-4039(03)01173-0

Cite this

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title = "A divergent approach to apoptolidin and FD-891: Asymmetric preparation of a common intermediate",

abstract = "Biologically active Apoptolidin and FD-891 have structural similarity in their macrocyclic cores. Asymmetric preparation of a common intermediate in the total synthesis of these two macrolides is presented. A modified Masuyama Sn-allylation was employed to control the relative stereochemistry in the synthesis of the intermediate.",

keywords = "Apoptolidin, Divergent synthesis, FD-891",

author = "Chng, {Shu Sin} and Jia Xu and Loh, {Teck Peng}",

year = "2003",

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T1 - A divergent approach to apoptolidin and FD-891

T2 - Asymmetric preparation of a common intermediate

AU - Chng, Shu Sin

AU - Xu, Jia

AU - Loh, Teck Peng

PY - 2003/6/30

Y1 - 2003/6/30

N2 - Biologically active Apoptolidin and FD-891 have structural similarity in their macrocyclic cores. Asymmetric preparation of a common intermediate in the total synthesis of these two macrolides is presented. A modified Masuyama Sn-allylation was employed to control the relative stereochemistry in the synthesis of the intermediate.

AB - Biologically active Apoptolidin and FD-891 have structural similarity in their macrocyclic cores. Asymmetric preparation of a common intermediate in the total synthesis of these two macrolides is presented. A modified Masuyama Sn-allylation was employed to control the relative stereochemistry in the synthesis of the intermediate.

KW - Apoptolidin

KW - Divergent synthesis

KW - FD-891

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U2 - 10.1016/S0040-4039(03)01173-0

DO - 10.1016/S0040-4039(03)01173-0

M3 - Article

AN - SCOPUS:0038519292

SN - 0040-4039

VL - 44

SP - 4997

EP - 5000

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 27

ER -

A divergent approach to apoptolidin and FD-891: Asymmetric preparation of a common intermediate

Abstract

ASJC Scopus Subject Areas

Keywords

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