A double masked placebo controlled study on the effect of nifedipine on optic nerve blood flow and visual field function in patients with open angle glaucoma

Georg Rainer; Barbara Kiss; Susanne Dallinger; Oliver Findl; Michael Georgopoulos; Clemens Vass; Rupert Menapace; Kaija Polak; Hans Georg Eichler; Michael Wolzt; Leopold Schmetterer

doi:10.1046/j.0306-5251.2001.01432.x

A double masked placebo controlled study on the effect of nifedipine on optic nerve blood flow and visual field function in patients with open angle glaucoma

Georg Rainer, Barbara Kiss, Susanne Dallinger, Oliver Findl, Michael Georgopoulos, Clemens Vass, Rupert Menapace, Kaija Polak, Hans Georg Eichler, Michael Wolzt, Leopold Schmetterer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Aims: To investigate whether nifedipine affects ocular perfusion or visual fields in open angle glaucoma patients. Methods: In a parallel group study nifedipine or placebo was administered for 3 months (n = 30). Ocular fundus pulsation amplitude (FPA), cup blood flow (Flowcup) and visual field mean deviation (MD) were measured. Results: Five patients receiving nifedipine discontinued due to adverse events. Nifedipine did not affect FPA [difference: 0.3 μm (95% CI -0.3,0.9); P = 0.70], Flow_cup: [difference: -9 rel.units (95% CI -133,114); P = 0.99], or MD [difference: 0.2dB (95% CI -2.2,2.7); P = 0.51] vs placebo. Conclusions: Systemic nifedipine is not well tolerated in glaucoma patients and exerts no effect on visual fields or ocular perfusion.

Original language	English
Pages (from-to)	210-212
Number of pages	3
Journal	British Journal of Clinical Pharmacology
Volume	52
Issue number	2
DOIs	https://doi.org/10.1046/j.0306-5251.2001.01432.x
Publication status	Published - 2001
Externally published	Yes

ASJC Scopus Subject Areas

Pharmacology
Pharmacology (medical)

Keywords

Calcium channel blockers
Glaucoma
Ocular blood flow
Visual field

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10.1046/j.0306-5251.2001.01432.x

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Rainer, G., Kiss, B., Dallinger, S., Findl, O., Georgopoulos, M., Vass, C., Menapace, R., Polak, K., Eichler, H. G., Wolzt, M., & Schmetterer, L. (2001). A double masked placebo controlled study on the effect of nifedipine on optic nerve blood flow and visual field function in patients with open angle glaucoma. British Journal of Clinical Pharmacology, 52(2), 210-212. https://doi.org/10.1046/j.0306-5251.2001.01432.x

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title = "A double masked placebo controlled study on the effect of nifedipine on optic nerve blood flow and visual field function in patients with open angle glaucoma",

abstract = "Aims: To investigate whether nifedipine affects ocular perfusion or visual fields in open angle glaucoma patients. Methods: In a parallel group study nifedipine or placebo was administered for 3 months (n = 30). Ocular fundus pulsation amplitude (FPA), cup blood flow (Flowcup) and visual field mean deviation (MD) were measured. Results: Five patients receiving nifedipine discontinued due to adverse events. Nifedipine did not affect FPA [difference: 0.3 μm (95% CI -0.3,0.9); P = 0.70], Flowcup: [difference: -9 rel.units (95% CI -133,114); P = 0.99], or MD [difference: 0.2dB (95% CI -2.2,2.7); P = 0.51] vs placebo. Conclusions: Systemic nifedipine is not well tolerated in glaucoma patients and exerts no effect on visual fields or ocular perfusion.",

keywords = "Calcium channel blockers, Glaucoma, Ocular blood flow, Visual field",

author = "Georg Rainer and Barbara Kiss and Susanne Dallinger and Oliver Findl and Michael Georgopoulos and Clemens Vass and Rupert Menapace and Kaija Polak and Eichler, {Hans Georg} and Michael Wolzt and Leopold Schmetterer",

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doi = "10.1046/j.0306-5251.2001.01432.x",

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Rainer, G, Kiss, B, Dallinger, S, Findl, O, Georgopoulos, M, Vass, C, Menapace, R, Polak, K, Eichler, HG, Wolzt, M & Schmetterer, L 2001, 'A double masked placebo controlled study on the effect of nifedipine on optic nerve blood flow and visual field function in patients with open angle glaucoma', British Journal of Clinical Pharmacology, vol. 52, no. 2, pp. 210-212. https://doi.org/10.1046/j.0306-5251.2001.01432.x

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T1 - A double masked placebo controlled study on the effect of nifedipine on optic nerve blood flow and visual field function in patients with open angle glaucoma

AU - Rainer, Georg

AU - Kiss, Barbara

AU - Dallinger, Susanne

AU - Findl, Oliver

AU - Georgopoulos, Michael

AU - Vass, Clemens

AU - Menapace, Rupert

AU - Polak, Kaija

AU - Eichler, Hans Georg

AU - Wolzt, Michael

AU - Schmetterer, Leopold

PY - 2001

Y1 - 2001

N2 - Aims: To investigate whether nifedipine affects ocular perfusion or visual fields in open angle glaucoma patients. Methods: In a parallel group study nifedipine or placebo was administered for 3 months (n = 30). Ocular fundus pulsation amplitude (FPA), cup blood flow (Flowcup) and visual field mean deviation (MD) were measured. Results: Five patients receiving nifedipine discontinued due to adverse events. Nifedipine did not affect FPA [difference: 0.3 μm (95% CI -0.3,0.9); P = 0.70], Flowcup: [difference: -9 rel.units (95% CI -133,114); P = 0.99], or MD [difference: 0.2dB (95% CI -2.2,2.7); P = 0.51] vs placebo. Conclusions: Systemic nifedipine is not well tolerated in glaucoma patients and exerts no effect on visual fields or ocular perfusion.

AB - Aims: To investigate whether nifedipine affects ocular perfusion or visual fields in open angle glaucoma patients. Methods: In a parallel group study nifedipine or placebo was administered for 3 months (n = 30). Ocular fundus pulsation amplitude (FPA), cup blood flow (Flowcup) and visual field mean deviation (MD) were measured. Results: Five patients receiving nifedipine discontinued due to adverse events. Nifedipine did not affect FPA [difference: 0.3 μm (95% CI -0.3,0.9); P = 0.70], Flowcup: [difference: -9 rel.units (95% CI -133,114); P = 0.99], or MD [difference: 0.2dB (95% CI -2.2,2.7); P = 0.51] vs placebo. Conclusions: Systemic nifedipine is not well tolerated in glaucoma patients and exerts no effect on visual fields or ocular perfusion.

KW - Calcium channel blockers

KW - Glaucoma

KW - Ocular blood flow

KW - Visual field

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A double masked placebo controlled study on the effect of nifedipine on optic nerve blood flow and visual field function in patients with open angle glaucoma

Abstract

ASJC Scopus Subject Areas

Keywords

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