A facile synthesis of 3,5-dimethyl-4-hydroxybenzaldehyde via copper-mediated selective oxidation of 2,4,6-trimethylphenol

Xiaojiao Sun; Zaher M.A. Judeh; Basem F. Ali; Solhe F. Alshahateet

doi:10.1016/j.cattod.2007.10.062

A facile synthesis of 3,5-dimethyl-4-hydroxybenzaldehyde via copper-mediated selective oxidation of 2,4,6-trimethylphenol

Xiaojiao Sun, Zaher M.A. Judeh^*, Basem F. Ali, Solhe F. Alshahateet

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

2,4,6-Trimethylphenol was selectively oxidized to 3,5-dimethyl-4-hydroxybenzaldehyde in very good yields using catalytic or equivalent amounts of CuCl₂ in the presence of K₂CO₃ and H₂O₂ in i-PrOH at 65 °C. The effect of the molar ratios of CuCl₂, K₂CO₃ and H₂O₂ on the yields and product distribution was examined. The oxidation reaction was found to proceed smoothly without the use of additives or ligands which were reported to be necessary.

Original language	English
Pages (from-to)	423-426
Number of pages	4
Journal	Catalysis Today
Volume	131
Issue number	1-4
DOIs	https://doi.org/10.1016/j.cattod.2007.10.062
Publication status	Published - Feb 29 2008
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry

Keywords

2,6-Dimethyl-4-(isopropoxymethyl)phenol
3,5-Dimethyl-4-hydroxybenzaldehyde
Copper(II) chloride
Mesitol
Oxidation

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10.1016/j.cattod.2007.10.062

Cite this

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title = "A facile synthesis of 3,5-dimethyl-4-hydroxybenzaldehyde via copper-mediated selective oxidation of 2,4,6-trimethylphenol",

abstract = "2,4,6-Trimethylphenol was selectively oxidized to 3,5-dimethyl-4-hydroxybenzaldehyde in very good yields using catalytic or equivalent amounts of CuCl2 in the presence of K2CO3 and H2O2 in i-PrOH at 65 °C. The effect of the molar ratios of CuCl2, K2CO3 and H2O2 on the yields and product distribution was examined. The oxidation reaction was found to proceed smoothly without the use of additives or ligands which were reported to be necessary.",

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AU - Sun, Xiaojiao

AU - Judeh, Zaher M.A.

AU - Ali, Basem F.

AU - Alshahateet, Solhe F.

PY - 2008/2/29

Y1 - 2008/2/29

N2 - 2,4,6-Trimethylphenol was selectively oxidized to 3,5-dimethyl-4-hydroxybenzaldehyde in very good yields using catalytic or equivalent amounts of CuCl2 in the presence of K2CO3 and H2O2 in i-PrOH at 65 °C. The effect of the molar ratios of CuCl2, K2CO3 and H2O2 on the yields and product distribution was examined. The oxidation reaction was found to proceed smoothly without the use of additives or ligands which were reported to be necessary.

AB - 2,4,6-Trimethylphenol was selectively oxidized to 3,5-dimethyl-4-hydroxybenzaldehyde in very good yields using catalytic or equivalent amounts of CuCl2 in the presence of K2CO3 and H2O2 in i-PrOH at 65 °C. The effect of the molar ratios of CuCl2, K2CO3 and H2O2 on the yields and product distribution was examined. The oxidation reaction was found to proceed smoothly without the use of additives or ligands which were reported to be necessary.

KW - 2,6-Dimethyl-4-(isopropoxymethyl)phenol

KW - 3,5-Dimethyl-4-hydroxybenzaldehyde

KW - Copper(II) chloride

KW - Mesitol

KW - Oxidation

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DO - 10.1016/j.cattod.2007.10.062

M3 - Article

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SN - 0920-5861

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IS - 1-4

ER -

A facile synthesis of 3,5-dimethyl-4-hydroxybenzaldehyde via copper-mediated selective oxidation of 2,4,6-trimethylphenol

Abstract

ASJC Scopus Subject Areas

Keywords

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