@inproceedings{6905f5e27d5c4fb3aaee47296d0f34ad,
title = "A microrobotic adherent cell injection system for investigating intracellular behavior of quantum dots",
abstract = "This paper presents a semi-automated microrobotic system for adherent cell injection. Different from embryos/oocytes that have a spherical shape and regular morphology, adherent cells are flat with a thickness of a few micrometers and are highly irregular in morphology. Based on computer vision microscopy and motion control, the system coordinately controls a three-degrees-of-freedom microrobot and a precision XY stage. The microrobotic system demonstrates an injection speed of 25 endothelial cells per minute with a survival rate of 96% and a success rate of 82% (n=1012). The system has a high degree of performance consistency. It is immune to operator proficiency variations and from human fatigue, requiring a human operator to select injection destinations through computer mouse clicking as the only operator intervention. The microrobotic adherent cell injection system makes the injection of thousands of adherent cells practical and will enable our testing of intracellular behavior of semiconductive quantum dots (QDs).",
keywords = "Adherent cell, Endothelial cells, Microrobotic injection, Molecule screening, Quantum dots",
author = "Wang, {W. H.} and Y. Sun and M. Zhang and R. Anderson and L. Langille and W. Chan",
year = "2008",
doi = "10.1109/ROBOT.2008.4543241",
language = "English",
isbn = "9781424416479",
series = "Proceedings - IEEE International Conference on Robotics and Automation",
pages = "407--412",
booktitle = "2008 IEEE International Conference on Robotics and Automation, ICRA 2008",
note = "2008 IEEE International Conference on Robotics and Automation, ICRA 2008 ; Conference date: 19-05-2008 Through 23-05-2008",
}