A novel biointerface with high-density polymer brush

Chiaki Yoshikawa; Atsushi Goto; Yoshinobu Tsujii; Takeshi Fukuda; Kazuya Yamamoto; Tsuyoshi Kimura; Akio Kishida

A novel biointerface with high-density polymer brush

Chiaki Yoshikawa^*, Atsushi Goto, Yoshinobu Tsujii, Takeshi Fukuda, Kazuya Yamamoto, Tsuyoshi Kimura, Akio Kishida

^*Corresponding author for this work

Research output: Contribution to conference › Paper › peer-review

2 Citations (Scopus)

Abstract

The protein adsorption was examined for the high-density (0.7 chains/nm ²), middle-density (0.1 chains/nm ²) and low-density (0.01 chains/nm ²) poly(2-hydroxyethyl methacrylate) (PHEMA) brush surfaces by a quartz crystal microbalance (QCM) and a fluorescence microscope. The high-density PHEMA brush significantly suppressed the adsorption of proteins compared with lower-density brushes, suggesting that the graft density is an important factor for the protein adsorption. The strong resistance to the protein adsorption for the high-density brush would be due to the size-exclusion effect, which can prevent the protein from permeating into the swollen brush layer due to the limited free space.

Original language	English
Pages	5151-5152
Number of pages	2
Publication status	Published - 2005
Externally published	Yes
Event	54th SPSJ Symposium on Macromolecules - Yamagata, Japan Duration: Sept 20 2005 → Sept 22 2005

Conference

Conference	54th SPSJ Symposium on Macromolecules
Country/Territory	Japan
City	Yamagata
Period	9/20/05 → 9/22/05

ASJC Scopus Subject Areas

General Engineering

Keywords

Biointerface
Living radical polymerization
Poly(2-hydroxyethyl methacrylate)
Polymer brush
Protein adsorption
QCM

Cite this

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title = "A novel biointerface with high-density polymer brush",

abstract = "The protein adsorption was examined for the high-density (0.7 chains/nm 2), middle-density (0.1 chains/nm 2) and low-density (0.01 chains/nm 2) poly(2-hydroxyethyl methacrylate) (PHEMA) brush surfaces by a quartz crystal microbalance (QCM) and a fluorescence microscope. The high-density PHEMA brush significantly suppressed the adsorption of proteins compared with lower-density brushes, suggesting that the graft density is an important factor for the protein adsorption. The strong resistance to the protein adsorption for the high-density brush would be due to the size-exclusion effect, which can prevent the protein from permeating into the swollen brush layer due to the limited free space.",

keywords = "Biointerface, Living radical polymerization, Poly(2-hydroxyethyl methacrylate), Polymer brush, Protein adsorption, QCM",

author = "Chiaki Yoshikawa and Atsushi Goto and Yoshinobu Tsujii and Takeshi Fukuda and Kazuya Yamamoto and Tsuyoshi Kimura and Akio Kishida",

year = "2005",

language = "English",

pages = "5151--5152",

note = "54th SPSJ Symposium on Macromolecules ; Conference date: 20-09-2005 Through 22-09-2005",

}

TY - CONF

T1 - A novel biointerface with high-density polymer brush

AU - Yoshikawa, Chiaki

AU - Goto, Atsushi

AU - Tsujii, Yoshinobu

AU - Fukuda, Takeshi

AU - Yamamoto, Kazuya

AU - Kimura, Tsuyoshi

AU - Kishida, Akio

PY - 2005

Y1 - 2005

N2 - The protein adsorption was examined for the high-density (0.7 chains/nm 2), middle-density (0.1 chains/nm 2) and low-density (0.01 chains/nm 2) poly(2-hydroxyethyl methacrylate) (PHEMA) brush surfaces by a quartz crystal microbalance (QCM) and a fluorescence microscope. The high-density PHEMA brush significantly suppressed the adsorption of proteins compared with lower-density brushes, suggesting that the graft density is an important factor for the protein adsorption. The strong resistance to the protein adsorption for the high-density brush would be due to the size-exclusion effect, which can prevent the protein from permeating into the swollen brush layer due to the limited free space.

AB - The protein adsorption was examined for the high-density (0.7 chains/nm 2), middle-density (0.1 chains/nm 2) and low-density (0.01 chains/nm 2) poly(2-hydroxyethyl methacrylate) (PHEMA) brush surfaces by a quartz crystal microbalance (QCM) and a fluorescence microscope. The high-density PHEMA brush significantly suppressed the adsorption of proteins compared with lower-density brushes, suggesting that the graft density is an important factor for the protein adsorption. The strong resistance to the protein adsorption for the high-density brush would be due to the size-exclusion effect, which can prevent the protein from permeating into the swollen brush layer due to the limited free space.

KW - Biointerface

KW - Living radical polymerization

KW - Poly(2-hydroxyethyl methacrylate)

KW - Polymer brush

KW - Protein adsorption

KW - QCM

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M3 - Paper

AN - SCOPUS:33645575352

SP - 5151

EP - 5152

T2 - 54th SPSJ Symposium on Macromolecules

Y2 - 20 September 2005 through 22 September 2005

ER -

A novel biointerface with high-density polymer brush

Abstract

Conference

ASJC Scopus Subject Areas

Keywords

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