A Periosteum-Inspired 3D Hydrogel-Bioceramic Composite for Enhanced Bone Regeneration

Yong Yao Chun; Jun Kit Wang; Nguan Soon Tan; Peggy Puk Yik Chan; Timothy Thatt Yang Tan; Cleo Choong

doi:10.1002/mabi.201500258

A Periosteum-Inspired 3D Hydrogel-Bioceramic Composite for Enhanced Bone Regeneration

Yong Yao Chun, Jun Kit Wang, Nguan Soon Tan, Peggy Puk Yik Chan, Timothy Thatt Yang Tan^*, Cleo Choong

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A 3D injectable hydrogel-bioceramic composite consisting of gelatin-3-(4-hydroxyphenyl) propionic acid (Gtn-HPA) and carboxymethyl cellulose-tyramine (CMC-Tyr), incorporated with fish scale-derived calcium phosphate (CaP), is developed for bone applications. The hydrogel-bioceramic composite has significantly improved the elastic modulus compared to the non-filled hydrogel, of which the addition of 10 w/v% CaP showed zero order fluorescein isothiocyanate (FITC)-dextran release profile and a significantly higher proliferation rate of encapsulated cells. All the samples promote the nucleation and growth of CaP minerals when exposed to 1× SBF. Overall, the hydrogel-bioceramic composite with 10 w/v% CaP can potentially be used as a periosteum-mimicking membrane to facilitate bone regeneration.

Original language	English
Pages (from-to)	276-287
Number of pages	12
Journal	Macromolecular Bioscience
Volume	16
Issue number	2
DOIs	https://doi.org/10.1002/mabi.201500258
Publication status	Published - Feb 1 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

ASJC Scopus Subject Areas

Biotechnology
Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

Keywords

biocompatibility
biomaterial
biomineralization
biopolymers
hydrogels

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10.1002/mabi.201500258

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abstract = "A 3D injectable hydrogel-bioceramic composite consisting of gelatin-3-(4-hydroxyphenyl) propionic acid (Gtn-HPA) and carboxymethyl cellulose-tyramine (CMC-Tyr), incorporated with fish scale-derived calcium phosphate (CaP), is developed for bone applications. The hydrogel-bioceramic composite has significantly improved the elastic modulus compared to the non-filled hydrogel, of which the addition of 10 w/v\% CaP showed zero order fluorescein isothiocyanate (FITC)-dextran release profile and a significantly higher proliferation rate of encapsulated cells. All the samples promote the nucleation and growth of CaP minerals when exposed to 1× SBF. Overall, the hydrogel-bioceramic composite with 10 w/v\% CaP can potentially be used as a periosteum-mimicking membrane to facilitate bone regeneration.",

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doi = "10.1002/mabi.201500258",

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AU - Chun, Yong Yao

AU - Wang, Jun Kit

AU - Tan, Nguan Soon

AU - Chan, Peggy Puk Yik

AU - Tan, Timothy Thatt Yang

AU - Choong, Cleo

PY - 2016/2/1

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N2 - A 3D injectable hydrogel-bioceramic composite consisting of gelatin-3-(4-hydroxyphenyl) propionic acid (Gtn-HPA) and carboxymethyl cellulose-tyramine (CMC-Tyr), incorporated with fish scale-derived calcium phosphate (CaP), is developed for bone applications. The hydrogel-bioceramic composite has significantly improved the elastic modulus compared to the non-filled hydrogel, of which the addition of 10 w/v% CaP showed zero order fluorescein isothiocyanate (FITC)-dextran release profile and a significantly higher proliferation rate of encapsulated cells. All the samples promote the nucleation and growth of CaP minerals when exposed to 1× SBF. Overall, the hydrogel-bioceramic composite with 10 w/v% CaP can potentially be used as a periosteum-mimicking membrane to facilitate bone regeneration.

AB - A 3D injectable hydrogel-bioceramic composite consisting of gelatin-3-(4-hydroxyphenyl) propionic acid (Gtn-HPA) and carboxymethyl cellulose-tyramine (CMC-Tyr), incorporated with fish scale-derived calcium phosphate (CaP), is developed for bone applications. The hydrogel-bioceramic composite has significantly improved the elastic modulus compared to the non-filled hydrogel, of which the addition of 10 w/v% CaP showed zero order fluorescein isothiocyanate (FITC)-dextran release profile and a significantly higher proliferation rate of encapsulated cells. All the samples promote the nucleation and growth of CaP minerals when exposed to 1× SBF. Overall, the hydrogel-bioceramic composite with 10 w/v% CaP can potentially be used as a periosteum-mimicking membrane to facilitate bone regeneration.

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KW - biomaterial

KW - biomineralization

KW - biopolymers

KW - hydrogels

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A Periosteum-Inspired 3D Hydrogel-Bioceramic Composite for Enhanced Bone Regeneration

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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