A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine

Chuncai Zhou; Peng Li; Xiaobao Qi; Abdul Rahim Mohamed Sharif; Yin Fun Poon; Ye Cao; Matthew W. Chang; Susanna Su Jan Leong; Mary B. Chan-Park

doi:10.1016/j.biomaterials.2010.12.040

A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine

Chuncai Zhou, Peng Li, Xiaobao Qi, Abdul Rahim Mohamed Sharif, Yin Fun Poon, Ye Cao, Matthew W. Chang^*, Susanna Su Jan Leong, Mary B. Chan-Park

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

223 Citations (Scopus)

Abstract

Hydrogels made from epsilon-poly- l-lysine-graft-methacrylamide (EPL-MA) have been found to have impressive wide spectrum antimicrobial activity against both bacteria (specifically Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens and Staphylococcus aureus) and fungi (specifically Candida albicans and Fusarium solani). The EPL-MA hydrogel also possesses in vitro biocompatibility and EPL-MA solution is relatively non-hemolytic: the concentration needed for onset of human red blood cell (hRBC) hemolysis is 12,500 μg/mL so that the selectivity for the pathogenic microorganisms over hRBCs is 230-1560. Further, EPL-MA hydrogel can be conveniently ultraviolet-immobilized onto plasma-treated plastic surfaces to form thin highly adherent antimicrobial hydrogel coatings for medical devices and implants.

Original language	English
Pages (from-to)	2704-2712
Number of pages	9
Journal	Biomaterials
Volume	32
Issue number	11
DOIs	https://doi.org/10.1016/j.biomaterials.2010.12.040
Publication status	Published - Apr 2011
Externally published	Yes

ASJC Scopus Subject Areas

Biophysics
Bioengineering
Ceramics and Composites
Biomaterials
Mechanics of Materials

Keywords

Antimicrobial peptide
Contact-active coating
Epsilon-poly-l-lysine
Graft
Hemolysis
Hydrogel

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10.1016/j.biomaterials.2010.12.040

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title = "A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine",

abstract = "Hydrogels made from epsilon-poly- l-lysine-graft-methacrylamide (EPL-MA) have been found to have impressive wide spectrum antimicrobial activity against both bacteria (specifically Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens and Staphylococcus aureus) and fungi (specifically Candida albicans and Fusarium solani). The EPL-MA hydrogel also possesses in vitro biocompatibility and EPL-MA solution is relatively non-hemolytic: the concentration needed for onset of human red blood cell (hRBC) hemolysis is 12,500 μg/mL so that the selectivity for the pathogenic microorganisms over hRBCs is 230-1560. Further, EPL-MA hydrogel can be conveniently ultraviolet-immobilized onto plasma-treated plastic surfaces to form thin highly adherent antimicrobial hydrogel coatings for medical devices and implants.",

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author = "Chuncai Zhou and Peng Li and Xiaobao Qi and Sharif, {Abdul Rahim Mohamed} and Poon, {Yin Fun} and Ye Cao and Chang, {Matthew W.} and Leong, {Susanna Su Jan} and Chan-Park, {Mary B.}",

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AU - Li, Peng

AU - Qi, Xiaobao

AU - Sharif, Abdul Rahim Mohamed

AU - Poon, Yin Fun

AU - Cao, Ye

AU - Chang, Matthew W.

AU - Leong, Susanna Su Jan

AU - Chan-Park, Mary B.

PY - 2011/4

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N2 - Hydrogels made from epsilon-poly- l-lysine-graft-methacrylamide (EPL-MA) have been found to have impressive wide spectrum antimicrobial activity against both bacteria (specifically Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens and Staphylococcus aureus) and fungi (specifically Candida albicans and Fusarium solani). The EPL-MA hydrogel also possesses in vitro biocompatibility and EPL-MA solution is relatively non-hemolytic: the concentration needed for onset of human red blood cell (hRBC) hemolysis is 12,500 μg/mL so that the selectivity for the pathogenic microorganisms over hRBCs is 230-1560. Further, EPL-MA hydrogel can be conveniently ultraviolet-immobilized onto plasma-treated plastic surfaces to form thin highly adherent antimicrobial hydrogel coatings for medical devices and implants.

AB - Hydrogels made from epsilon-poly- l-lysine-graft-methacrylamide (EPL-MA) have been found to have impressive wide spectrum antimicrobial activity against both bacteria (specifically Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens and Staphylococcus aureus) and fungi (specifically Candida albicans and Fusarium solani). The EPL-MA hydrogel also possesses in vitro biocompatibility and EPL-MA solution is relatively non-hemolytic: the concentration needed for onset of human red blood cell (hRBC) hemolysis is 12,500 μg/mL so that the selectivity for the pathogenic microorganisms over hRBCs is 230-1560. Further, EPL-MA hydrogel can be conveniently ultraviolet-immobilized onto plasma-treated plastic surfaces to form thin highly adherent antimicrobial hydrogel coatings for medical devices and implants.

KW - Antimicrobial peptide

KW - Contact-active coating

KW - Epsilon-poly-l-lysine

KW - Graft

KW - Hemolysis

KW - Hydrogel

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A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine

Abstract

ASJC Scopus Subject Areas

Keywords

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