A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis

Kizito Njah; Sayan Chakraborty; Beiying Qiu; Surender Arumugam; Anandhkumar Raju; Ajaybabu V. Pobbati; Manikandan Lakshmanan; Vinay Tergaonkar; Guillaume Thibault; Xiaomeng Wang; Wanjin Hong

doi:10.1016/j.celrep.2019.06.036

A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis

Kizito Njah, Sayan Chakraborty^*, Beiying Qiu, Surender Arumugam, Anandhkumar Raju, Ajaybabu V. Pobbati, Manikandan Lakshmanan, Vinay Tergaonkar, Guillaume Thibault, Xiaomeng Wang, Wanjin Hong

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Njah et. al. show that the extracellular matrix protein Agrin recruits blood vessels within tumors. Agrin promotes adherence of endothelial cells (ECs) to tumor cells and enhances tumor angiogenesis. Mechanistically, matrix stiffness and Agrin stabilize VEGFR2 by enhancing interactions with Lrp4-Integrin-β1-FAK. Targeting Agrin may inhibit tumor angiogenesis by reducing VEGFR2 levels.

Original language	English
Pages (from-to)	949-965.e7
Journal	Cell Reports
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.celrep.2019.06.036
Publication status	Published - Jul 23 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 The Author(s)

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology

Keywords

Agrin
angiogenesis
cell adhesion
ECM stiffness
endothelial-NOS
focal adhesion kinase (FAK)
integrins
tumor angiogenesis
VEGFR2

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10.1016/j.celrep.2019.06.036

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title = "A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis",

abstract = "Njah et. al. show that the extracellular matrix protein Agrin recruits blood vessels within tumors. Agrin promotes adherence of endothelial cells (ECs) to tumor cells and enhances tumor angiogenesis. Mechanistically, matrix stiffness and Agrin stabilize VEGFR2 by enhancing interactions with Lrp4-Integrin-β1-FAK. Targeting Agrin may inhibit tumor angiogenesis by reducing VEGFR2 levels.",

keywords = "Agrin, angiogenesis, cell adhesion, ECM stiffness, endothelial-NOS, focal adhesion kinase (FAK), integrins, tumor angiogenesis, VEGFR2",

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AU - Njah, Kizito

AU - Chakraborty, Sayan

AU - Qiu, Beiying

AU - Arumugam, Surender

AU - Raju, Anandhkumar

AU - Pobbati, Ajaybabu V.

AU - Lakshmanan, Manikandan

AU - Tergaonkar, Vinay

AU - Thibault, Guillaume

AU - Wang, Xiaomeng

AU - Hong, Wanjin

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AB - Njah et. al. show that the extracellular matrix protein Agrin recruits blood vessels within tumors. Agrin promotes adherence of endothelial cells (ECs) to tumor cells and enhances tumor angiogenesis. Mechanistically, matrix stiffness and Agrin stabilize VEGFR2 by enhancing interactions with Lrp4-Integrin-β1-FAK. Targeting Agrin may inhibit tumor angiogenesis by reducing VEGFR2 levels.

KW - Agrin

KW - angiogenesis

KW - cell adhesion

KW - ECM stiffness

KW - endothelial-NOS

KW - focal adhesion kinase (FAK)

KW - integrins

KW - tumor angiogenesis

KW - VEGFR2

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A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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