A self-adhesive microneedle patch with drug loading capability through swelling effect

Sharon W.T. Chew; Ankur H. Shah; Mengjia Zheng; Hao Chang; Christian Wiraja; Terry W.J. Steele; Chenjie Xu

doi:10.1002/btm2.10157

A self-adhesive microneedle patch with drug loading capability through swelling effect

Sharon W.T. Chew, Ankur H. Shah, Mengjia Zheng, Hao Chang, Christian Wiraja, Terry W.J. Steele, Chenjie Xu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug-loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylated hyaluronic acid (MeHA). The post-fabrication drug loading process allows MeHA MN patches with drug loadings of 10 μg cm⁻². Additional post-fabrication processes are explored with dendrimer bioadhesives that increase work of adhesion, ensuring stable fixation on skin, and allow for additional drug loading strategies.

Original language	English
Article number	e10157
Journal	Bioengineering and Translational Medicine
Volume	5
Issue number	2
DOIs	https://doi.org/10.1002/btm2.10157
Publication status	Published - May 1 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers.

ASJC Scopus Subject Areas

Biotechnology
Biomedical Engineering
Pharmaceutical Science

Keywords

bioadhesive
dendrimer
microneedles
self-adhesive
transdermal drug delivery

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10.1002/btm2.10157

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title = "A self-adhesive microneedle patch with drug loading capability through swelling effect",

abstract = "Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug-loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylated hyaluronic acid (MeHA). The post-fabrication drug loading process allows MeHA MN patches with drug loadings of 10 μg cm−2. Additional post-fabrication processes are explored with dendrimer bioadhesives that increase work of adhesion, ensuring stable fixation on skin, and allow for additional drug loading strategies.",

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AU - Chew, Sharon W.T.

AU - Shah, Ankur H.

AU - Zheng, Mengjia

AU - Chang, Hao

AU - Wiraja, Christian

AU - Steele, Terry W.J.

AU - Xu, Chenjie

PY - 2020/5/1

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A self-adhesive microneedle patch with drug loading capability through swelling effect

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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