A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue

Lewen Zheng; Dandan Zhu; Wenjun Wang; Jiyang Liu; Steven Tien Guan Thng; Peng Chen

doi:10.1016/j.snb.2022.132626

A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue

Lewen Zheng, Dandan Zhu, Wenjun Wang, Jiyang Liu, Steven Tien Guan Thng, Peng Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Glucose is critical to all organisms. Herein, we developed a wire electrode embedded microneedle patch (WEMNP) for in situ real-time detection of glucose in the interstitial fluid (ISF) of skin or plant tissues with minimal invasiveness. WEMNP is made of proline treated silk fibroin proteins, which provide good mechanical strength (0.75 N/microneedle) for tissue penetration and desirable bioelectronic interface for fast and high-fidelity detection. WEMNP shows specific and linear response to glucose between 3 and 18 mM for detection in skin ISF with a sensitivity of 21.21 nA/mM and between 30 and 180 mM for detection in plant ISF with a sensitivity of 1.22 nA/mM. Such self-administrable WEMNP could be instrumental to long-term home-based management for chronic diseases and to smart agriculturing.

Original language	English
Article number	132626
Journal	Sensors and Actuators, B: Chemical
Volume	372
DOIs	https://doi.org/10.1016/j.snb.2022.132626
Publication status	Published - Dec 1 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 Elsevier B.V.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

Keywords

Electrochemistry
Glucose detection
Interstitial skin fluid
Microneedles
Smart agriculturing

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10.1016/j.snb.2022.132626

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title = "A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue",

abstract = "Glucose is critical to all organisms. Herein, we developed a wire electrode embedded microneedle patch (WEMNP) for in situ real-time detection of glucose in the interstitial fluid (ISF) of skin or plant tissues with minimal invasiveness. WEMNP is made of proline treated silk fibroin proteins, which provide good mechanical strength (0.75 N/microneedle) for tissue penetration and desirable bioelectronic interface for fast and high-fidelity detection. WEMNP shows specific and linear response to glucose between 3 and 18 mM for detection in skin ISF with a sensitivity of 21.21 nA/mM and between 30 and 180 mM for detection in plant ISF with a sensitivity of 1.22 nA/mM. Such self-administrable WEMNP could be instrumental to long-term home-based management for chronic diseases and to smart agriculturing.",

keywords = "Electrochemistry, Glucose detection, Interstitial skin fluid, Microneedles, Smart agriculturing",

author = "Lewen Zheng and Dandan Zhu and Wenjun Wang and Jiyang Liu and Thng, {Steven Tien Guan} and Peng Chen",

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T1 - A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue

AU - Zheng, Lewen

AU - Zhu, Dandan

AU - Wang, Wenjun

AU - Liu, Jiyang

AU - Thng, Steven Tien Guan

AU - Chen, Peng

PY - 2022/12/1

Y1 - 2022/12/1

N2 - Glucose is critical to all organisms. Herein, we developed a wire electrode embedded microneedle patch (WEMNP) for in situ real-time detection of glucose in the interstitial fluid (ISF) of skin or plant tissues with minimal invasiveness. WEMNP is made of proline treated silk fibroin proteins, which provide good mechanical strength (0.75 N/microneedle) for tissue penetration and desirable bioelectronic interface for fast and high-fidelity detection. WEMNP shows specific and linear response to glucose between 3 and 18 mM for detection in skin ISF with a sensitivity of 21.21 nA/mM and between 30 and 180 mM for detection in plant ISF with a sensitivity of 1.22 nA/mM. Such self-administrable WEMNP could be instrumental to long-term home-based management for chronic diseases and to smart agriculturing.

AB - Glucose is critical to all organisms. Herein, we developed a wire electrode embedded microneedle patch (WEMNP) for in situ real-time detection of glucose in the interstitial fluid (ISF) of skin or plant tissues with minimal invasiveness. WEMNP is made of proline treated silk fibroin proteins, which provide good mechanical strength (0.75 N/microneedle) for tissue penetration and desirable bioelectronic interface for fast and high-fidelity detection. WEMNP shows specific and linear response to glucose between 3 and 18 mM for detection in skin ISF with a sensitivity of 21.21 nA/mM and between 30 and 180 mM for detection in plant ISF with a sensitivity of 1.22 nA/mM. Such self-administrable WEMNP could be instrumental to long-term home-based management for chronic diseases and to smart agriculturing.

KW - Electrochemistry

KW - Glucose detection

KW - Interstitial skin fluid

KW - Microneedles

KW - Smart agriculturing

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VL - 372

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

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ER -

A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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