A transition metal carbonyl probe for use in a highly specific and sensitive sers-based assay for glucose

Kien Voon Kong; Zhiyong Lam; Weber Kam On Lau; Weng Kee Leong; Malini Olivo

doi:10.1021/ja409230g

A transition metal carbonyl probe for use in a highly specific and sensitive sers-based assay for glucose

Kien Voon Kong, Zhiyong Lam, Weber Kam On Lau, Weng Kee Leong^*, Malini Olivo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

163 Citations (Scopus)

Abstract

A triosmium carbonyl cluster-boronic acid conjugate is used as a secondary carbohydrate probe in a SERS-based assay. The assay does not require conjugation of the metal carbonyl probe to a SERS-active species, and it utilizes the CO stretching vibrations of the metal carbonyl, which lies in a silent region of the SERS spectrum (1800-2200 cm^-1), for quantification. High selectivity for glucose over fructose and galactose is obtained, and a human urine sample doped with glucose is detected accurately.

Original language	English
Pages (from-to)	18028-18031
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	135
Issue number	48
DOIs	https://doi.org/10.1021/ja409230g
Publication status	Published - Dec 4 2013
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja409230g

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abstract = "A triosmium carbonyl cluster-boronic acid conjugate is used as a secondary carbohydrate probe in a SERS-based assay. The assay does not require conjugation of the metal carbonyl probe to a SERS-active species, and it utilizes the CO stretching vibrations of the metal carbonyl, which lies in a silent region of the SERS spectrum (1800-2200 cm-1), for quantification. High selectivity for glucose over fructose and galactose is obtained, and a human urine sample doped with glucose is detected accurately.",

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AU - Lam, Zhiyong

AU - Lau, Weber Kam On

AU - Leong, Weng Kee

AU - Olivo, Malini

PY - 2013/12/4

Y1 - 2013/12/4

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AB - A triosmium carbonyl cluster-boronic acid conjugate is used as a secondary carbohydrate probe in a SERS-based assay. The assay does not require conjugation of the metal carbonyl probe to a SERS-active species, and it utilizes the CO stretching vibrations of the metal carbonyl, which lies in a silent region of the SERS spectrum (1800-2200 cm-1), for quantification. High selectivity for glucose over fructose and galactose is obtained, and a human urine sample doped with glucose is detected accurately.

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A transition metal carbonyl probe for use in a highly specific and sensitive sers-based assay for glucose

Abstract

ASJC Scopus Subject Areas

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