A triosmium carbonyl cluster that inhibits α-synuclein aggregation and disassembles preformed aggregates

Xin Liang; Balasz Gulyas; Mathangi Palanivel; Weng Kee Leong

doi:10.1039/d5cc01141h

A triosmium carbonyl cluster that inhibits α-synuclein aggregation and disassembles preformed aggregates

Xin Liang, Balasz Gulyas, Mathangi Palanivel, Weng Kee Leong^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Two triosmium carbonyl clusters, viz., Os₃(μ-H)(μ-SC₆H₄-p-NO₂)(CO)₁₀ (1) and Os₃(μ-H)(kO,μ-O′-2-flavone)(CO)₉ (2), effectively inhibited α-synuclein aggregation, a key signature of Parkinson's disease (PD), in both wild-type and A53T-mutant α-synuclein models. Cluster 2 showed superior efficacy and a significantly better safety profile, and could also disassemble preformed aggregates.

Original language	English
Journal	Chemical Communications
DOIs	https://doi.org/10.1039/d5cc01141h
Publication status	Accepted/In press - 2025
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2025 The Royal Society of Chemistry.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Two triosmium carbonyl clusters, viz., Os3(μ-H)(μ-SC6H4-p-NO2)(CO)10 (1) and Os3(μ-H)(kO,μ-O′-2-flavone)(CO)9 (2), effectively inhibited α-synuclein aggregation, a key signature of Parkinson's disease (PD), in both wild-type and A53T-mutant α-synuclein models. Cluster 2 showed superior efficacy and a significantly better safety profile, and could also disassemble preformed aggregates.",

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AU - Liang, Xin

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AU - Palanivel, Mathangi

AU - Leong, Weng Kee

PY - 2025

Y1 - 2025

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AB - Two triosmium carbonyl clusters, viz., Os3(μ-H)(μ-SC6H4-p-NO2)(CO)10 (1) and Os3(μ-H)(kO,μ-O′-2-flavone)(CO)9 (2), effectively inhibited α-synuclein aggregation, a key signature of Parkinson's disease (PD), in both wild-type and A53T-mutant α-synuclein models. Cluster 2 showed superior efficacy and a significantly better safety profile, and could also disassemble preformed aggregates.

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A triosmium carbonyl cluster that inhibits α-synuclein aggregation and disassembles preformed aggregates

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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