Absence of A673T amyloid-β precursor protein variant in alzheimer's disease and other neurological diseases

Simon Kang Seng Ting; Mei Sian Chong; Nagaendran Kandiah; Shahul Hameed; Louis Tan; Wing Lok Au; Kumar M. Prakash; Ratnagopal Pavanni; Tih Shih Lee; Jia Nee Foo; Jin Xin Bei; Xue Qing Yu; Jian Jun Liu; Yi Zhao; Wei Ling Lee; Eng King Tan

doi:10.1016/j.neurobiolaging.2013.04.012

Absence of A673T amyloid-β precursor protein variant in alzheimer's disease and other neurological diseases

Simon Kang Seng Ting, Mei Sian Chong, Nagaendran Kandiah, Shahul Hameed, Louis Tan, Wing Lok Au, Kumar M. Prakash, Ratnagopal Pavanni, Tih Shih Lee, Jia Nee Foo, Jin Xin Bei, Xue Qing Yu, Jian Jun Liu, Yi Zhao, Wei Ling Lee, Eng King Tan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The rare variant A673T in the amyloid-β precursor protein (APP) gene has been shown to reduce the risk of cognitive impairment. We genotyped the variant in 8721 Asian individuals comprising 552 with Alzheimer's disease and vascular dementia, 790 with Parkinson's disease, and 7379 controls. The A673T variant was absent in all of the subjects. Our finding suggests that the A673T protective variant is not relevant in our Asian population. Studies in other ethnic populations would clarify whether this variant is specific to specific races/ethnicities.

Original language	English
Pages (from-to)	2441.e7-2441.e8
Journal	Neurobiology of Aging
Volume	34
Issue number	10
DOIs	https://doi.org/10.1016/j.neurobiolaging.2013.04.012
Publication status	Published - Oct 2013
Externally published	Yes

ASJC Scopus Subject Areas

General Neuroscience
Ageing
Developmental Biology
Clinical Neurology
Geriatrics and Gerontology

Keywords

A673T
Amyloid-beta precursor protein
Dementia

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10.1016/j.neurobiolaging.2013.04.012

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Ting, S. K. S., Chong, M. S., Kandiah, N., Hameed, S., Tan, L., Au, W. L., Prakash, K. M., Pavanni, R., Lee, T. S., Foo, J. N., Bei, J. X., Yu, X. Q., Liu, J. J., Zhao, Y., Lee, W. L., & Tan, E. K. (2013). Absence of A673T amyloid-β precursor protein variant in alzheimer's disease and other neurological diseases. Neurobiology of Aging, 34(10), 2441.e7-2441.e8. https://doi.org/10.1016/j.neurobiolaging.2013.04.012

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title = "Absence of A673T amyloid-β precursor protein variant in alzheimer's disease and other neurological diseases",

abstract = "The rare variant A673T in the amyloid-β precursor protein (APP) gene has been shown to reduce the risk of cognitive impairment. We genotyped the variant in 8721 Asian individuals comprising 552 with Alzheimer's disease and vascular dementia, 790 with Parkinson's disease, and 7379 controls. The A673T variant was absent in all of the subjects. Our finding suggests that the A673T protective variant is not relevant in our Asian population. Studies in other ethnic populations would clarify whether this variant is specific to specific races/ethnicities.",

keywords = "A673T, Amyloid-beta precursor protein, Dementia",

author = "Ting, \{Simon Kang Seng\} and Chong, \{Mei Sian\} and Nagaendran Kandiah and Shahul Hameed and Louis Tan and Au, \{Wing Lok\} and Prakash, \{Kumar M.\} and Ratnagopal Pavanni and Lee, \{Tih Shih\} and Foo, \{Jia Nee\} and Bei, \{Jin Xin\} and Yu, \{Xue Qing\} and Liu, \{Jian Jun\} and Yi Zhao and Lee, \{Wei Ling\} and Tan, \{Eng King\}",

year = "2013",

month = oct,

doi = "10.1016/j.neurobiolaging.2013.04.012",

language = "English",

volume = "34",

pages = "2441.e7--2441.e8",

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Ting, SKS, Chong, MS, Kandiah, N, Hameed, S, Tan, L, Au, WL, Prakash, KM, Pavanni, R, Lee, TS, Foo, JN, Bei, JX, Yu, XQ, Liu, JJ, Zhao, Y, Lee, WL & Tan, EK 2013, 'Absence of A673T amyloid-β precursor protein variant in alzheimer's disease and other neurological diseases', Neurobiology of Aging, vol. 34, no. 10, pp. 2441.e7-2441.e8. https://doi.org/10.1016/j.neurobiolaging.2013.04.012

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AU - Ting, Simon Kang Seng

AU - Chong, Mei Sian

AU - Kandiah, Nagaendran

AU - Hameed, Shahul

AU - Tan, Louis

AU - Au, Wing Lok

AU - Prakash, Kumar M.

AU - Pavanni, Ratnagopal

AU - Lee, Tih Shih

AU - Foo, Jia Nee

AU - Bei, Jin Xin

AU - Yu, Xue Qing

AU - Liu, Jian Jun

AU - Zhao, Yi

AU - Lee, Wei Ling

AU - Tan, Eng King

PY - 2013/10

Y1 - 2013/10

N2 - The rare variant A673T in the amyloid-β precursor protein (APP) gene has been shown to reduce the risk of cognitive impairment. We genotyped the variant in 8721 Asian individuals comprising 552 with Alzheimer's disease and vascular dementia, 790 with Parkinson's disease, and 7379 controls. The A673T variant was absent in all of the subjects. Our finding suggests that the A673T protective variant is not relevant in our Asian population. Studies in other ethnic populations would clarify whether this variant is specific to specific races/ethnicities.

AB - The rare variant A673T in the amyloid-β precursor protein (APP) gene has been shown to reduce the risk of cognitive impairment. We genotyped the variant in 8721 Asian individuals comprising 552 with Alzheimer's disease and vascular dementia, 790 with Parkinson's disease, and 7379 controls. The A673T variant was absent in all of the subjects. Our finding suggests that the A673T protective variant is not relevant in our Asian population. Studies in other ethnic populations would clarify whether this variant is specific to specific races/ethnicities.

KW - A673T

KW - Amyloid-beta precursor protein

KW - Dementia

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Absence of A673T amyloid-β precursor protein variant in alzheimer's disease and other neurological diseases

Abstract

ASJC Scopus Subject Areas

Keywords

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