Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction

Yuanlin Cai; Ya Lv; Liangzhen Shu; Zhichao Jin; Yonggui Robin Chi; Tingting Li

doi:10.34133/research.0293

Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction

Yuanlin Cai, Ya Lv, Liangzhen Shu, Zhichao Jin, Yonggui Robin Chi, Tingting Li^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

An approach utilizing N-heterocyclic carbene for nitrile formation and desymmetrization reaction is developed. The process involves kinetic resolution, with the axially chiral aryl monoaldehydes obtained in moderate yields with excellent optical purities. These axially chiral aryl monoaldehydes can be conveniently transformed into functionalized molecules, showing great potential as catalysts in organic chemistry.

Original language	English
Article number	0293
Journal	Research
Volume	7
DOIs	https://doi.org/10.34133/research.0293
Publication status	Published - 2024
Externally published	Yes

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© 2024 American Association for the Advancement of Science. All rights reserved.

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title = "Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction",

abstract = "An approach utilizing N-heterocyclic carbene for nitrile formation and desymmetrization reaction is developed. The process involves kinetic resolution, with the axially chiral aryl monoaldehydes obtained in moderate yields with excellent optical purities. These axially chiral aryl monoaldehydes can be conveniently transformed into functionalized molecules, showing great potential as catalysts in organic chemistry.",

author = "Yuanlin Cai and Ya Lv and Liangzhen Shu and Zhichao Jin and Chi, {Yonggui Robin} and Tingting Li",

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T1 - Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction

AU - Cai, Yuanlin

AU - Lv, Ya

AU - Shu, Liangzhen

AU - Jin, Zhichao

AU - Chi, Yonggui Robin

AU - Li, Tingting

PY - 2024

Y1 - 2024

N2 - An approach utilizing N-heterocyclic carbene for nitrile formation and desymmetrization reaction is developed. The process involves kinetic resolution, with the axially chiral aryl monoaldehydes obtained in moderate yields with excellent optical purities. These axially chiral aryl monoaldehydes can be conveniently transformed into functionalized molecules, showing great potential as catalysts in organic chemistry.

AB - An approach utilizing N-heterocyclic carbene for nitrile formation and desymmetrization reaction is developed. The process involves kinetic resolution, with the axially chiral aryl monoaldehydes obtained in moderate yields with excellent optical purities. These axially chiral aryl monoaldehydes can be conveniently transformed into functionalized molecules, showing great potential as catalysts in organic chemistry.

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Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction

Abstract

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