Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines

Lin Hao; Xingkuan Chen; Shaojin Chen; Ke Jiang; Jaume Torres; Yonggui Robin Chi

doi:10.1039/c3qo00045a

Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines

Lin Hao, Xingkuan Chen, Shaojin Chen, Ke Jiang, Jaume Torres, Yonggui Robin Chi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Facile access to trisubstituted pyridines from α-chloro acetic ester and unsaturated imines is achieved. DMAP-catalyzed activation of ester to form an enolate intermediate constitutes a key reaction step. On the application side, the wide availability and low cost of the substrates and catalysts make this method very attractive.

Original language	English
Pages (from-to)	148-150
Number of pages	3
Journal	Organic Chemistry Frontiers
Volume	1
Issue number	2
DOIs	https://doi.org/10.1039/c3qo00045a
Publication status	Published - Apr 1 2014
Externally published	Yes

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Publisher Copyright:
© 2015 Royal Society of Chemistry.

ASJC Scopus Subject Areas

Organic Chemistry

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abstract = "Facile access to trisubstituted pyridines from α-chloro acetic ester and unsaturated imines is achieved. DMAP-catalyzed activation of ester to form an enolate intermediate constitutes a key reaction step. On the application side, the wide availability and low cost of the substrates and catalysts make this method very attractive.",

author = "Lin Hao and Xingkuan Chen and Shaojin Chen and Ke Jiang and Jaume Torres and Chi, {Yonggui Robin}",

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AU - Hao, Lin

AU - Chen, Xingkuan

AU - Chen, Shaojin

AU - Jiang, Ke

AU - Torres, Jaume

AU - Chi, Yonggui Robin

PY - 2014/4/1

Y1 - 2014/4/1

N2 - Facile access to trisubstituted pyridines from α-chloro acetic ester and unsaturated imines is achieved. DMAP-catalyzed activation of ester to form an enolate intermediate constitutes a key reaction step. On the application side, the wide availability and low cost of the substrates and catalysts make this method very attractive.

AB - Facile access to trisubstituted pyridines from α-chloro acetic ester and unsaturated imines is achieved. DMAP-catalyzed activation of ester to form an enolate intermediate constitutes a key reaction step. On the application side, the wide availability and low cost of the substrates and catalysts make this method very attractive.

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Access to pyridines via DMAP-catalyzed activation of α-chloro acetic ester to react with unsaturated imines

Abstract

Bibliographical note

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