Accurate identification of human Alu and non-Alu RNA editing sites

Gokul Ramaswami; Wei Lin; Robert Piskol; Meng How Tan; Carrie Davis; Jin Billy Li

doi:10.1038/nmeth.1982

Accurate identification of human Alu and non-Alu RNA editing sites

Gokul Ramaswami, Wei Lin, Robert Piskol, Meng How Tan, Carrie Davis, Jin Billy Li^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

311 Citations (Scopus)

Abstract

We developed a computational framework to robustly identify RNA editing sites using transcriptome and genome deep-sequencing data from the same individual. As compared with previous methods, our approach identified a large number of Alu and non-Alu RNA editing sites with high specificity. We also found that editing of non-Alu sites appears to be dependent on nearby edited Alu sites, possibly through the locally formed double-stranded RNA structure.

Original language	English
Pages (from-to)	579-581
Number of pages	3
Journal	Nature Methods
Volume	9
Issue number	6
DOIs	https://doi.org/10.1038/nmeth.1982
Publication status	Published - Jun 2012
Externally published	Yes

ASJC Scopus Subject Areas

Biotechnology
Biochemistry
Molecular Biology
Cell Biology

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10.1038/nmeth.1982

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author = "Gokul Ramaswami and Wei Lin and Robert Piskol and Tan, {Meng How} and Carrie Davis and Li, {Jin Billy}",

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Accurate identification of human Alu and non-Alu RNA editing sites

Abstract

ASJC Scopus Subject Areas

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