Addition of indoles to oxyallyl cations for facile access to α-indole carbonyl compounds

Qiang Tang; Xingkuan Chen; Bhoopendra Tiwari; Yonggui Robin Chi

doi:10.1021/ol300591z

Addition of indoles to oxyallyl cations for facile access to α-indole carbonyl compounds

Qiang Tang, Xingkuan Chen, Bhoopendra Tiwari, Yonggui Robin Chi^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

A direct coupling of unprotected indoles and α-halo ketones via in situ generated oxyallyl cation intermediates is described. The reactions efficiently afford α-indole carbonyl compounds with good to quantitative yields.

Original language	English
Pages (from-to)	1922-1925
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	7
DOIs	https://doi.org/10.1021/ol300591z
Publication status	Published - Apr 6 2012
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol300591z

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title = "Addition of indoles to oxyallyl cations for facile access to α-indole carbonyl compounds",

abstract = "A direct coupling of unprotected indoles and α-halo ketones via in situ generated oxyallyl cation intermediates is described. The reactions efficiently afford α-indole carbonyl compounds with good to quantitative yields.",

author = "Qiang Tang and Xingkuan Chen and Bhoopendra Tiwari and Chi, {Yonggui Robin}",

year = "2012",

month = apr,

day = "6",

doi = "10.1021/ol300591z",

language = "English",

volume = "14",

pages = "1922--1925",

journal = "Organic Letters",

issn = "1523-7060",

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TY - JOUR

T1 - Addition of indoles to oxyallyl cations for facile access to α-indole carbonyl compounds

AU - Tang, Qiang

AU - Chen, Xingkuan

AU - Tiwari, Bhoopendra

AU - Chi, Yonggui Robin

PY - 2012/4/6

Y1 - 2012/4/6

N2 - A direct coupling of unprotected indoles and α-halo ketones via in situ generated oxyallyl cation intermediates is described. The reactions efficiently afford α-indole carbonyl compounds with good to quantitative yields.

AB - A direct coupling of unprotected indoles and α-halo ketones via in situ generated oxyallyl cation intermediates is described. The reactions efficiently afford α-indole carbonyl compounds with good to quantitative yields.

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U2 - 10.1021/ol300591z

DO - 10.1021/ol300591z

M3 - Article

C2 - 22455439

AN - SCOPUS:84859622403

SN - 1523-7060

VL - 14

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EP - 1925

JO - Organic Letters

JF - Organic Letters

IS - 7

ER -

Addition of indoles to oxyallyl cations for facile access to α-indole carbonyl compounds

Abstract

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