TY - JOUR
T1 - Adherence to gastroprotection and the risk of NSAID-related upper gastrointestinal ulcers and haemorrhage
AU - Van Soest, E. M.
AU - Sturkenboom, M. C.J.M.
AU - Dieleman, J. P.
AU - Verhamme, K. M.C.
AU - Siersema, P. D.
AU - Kuipers, E. J.
PY - 2007/7
Y1 - 2007/7
N2 - Background: Upper gastrointestinal (UGI) complications are a well-recognized risk of NSAID treatment, requiring preventive measures in high-risk patients. Adherence to gastroprotective agents (GPAs) in NSAID users has been suggested to be suboptimal. Aim: To investigate the association between adherence to GPAs (proton pump inhibitors or H2-receptor antagonists) and the risk of NSAID-related UGI ulcers or haemorrhage in high-risk patients. Methods: A population-based nested case-control study was conducted within a cohort of new NSAID users with at least one risk factor for a NSAID-related UGI complication, identified in the Dutch IPCI database during 1996-2005. Adherence to GPAs was calculated as the proportion of NSAID treatment days covered (PDC) by a GPA prescription. Multivariate conditional logistic regression analysis was used to calculate odds ratios with 95% confidence intervals (95% CI). Results: Fifteen percent of the non-selective NSAID users received GPAs. The risk of a NSAID-related UGI complication among NSAID users increased 16% for every 10% decrease in adherence. Compared to patients with a PDC of >80%, patients with PDCs of 20-80% and <20% had a 2.5-fold (95% CI: 1.0-6.7) respectively 4.0-fold (95% CI: 1.2-13.0) increased risk. Conclusion: There is a strong inverse relationship between adherence to GPAs and the risk of UGI complications in high-risk NSAID users.
AB - Background: Upper gastrointestinal (UGI) complications are a well-recognized risk of NSAID treatment, requiring preventive measures in high-risk patients. Adherence to gastroprotective agents (GPAs) in NSAID users has been suggested to be suboptimal. Aim: To investigate the association between adherence to GPAs (proton pump inhibitors or H2-receptor antagonists) and the risk of NSAID-related UGI ulcers or haemorrhage in high-risk patients. Methods: A population-based nested case-control study was conducted within a cohort of new NSAID users with at least one risk factor for a NSAID-related UGI complication, identified in the Dutch IPCI database during 1996-2005. Adherence to GPAs was calculated as the proportion of NSAID treatment days covered (PDC) by a GPA prescription. Multivariate conditional logistic regression analysis was used to calculate odds ratios with 95% confidence intervals (95% CI). Results: Fifteen percent of the non-selective NSAID users received GPAs. The risk of a NSAID-related UGI complication among NSAID users increased 16% for every 10% decrease in adherence. Compared to patients with a PDC of >80%, patients with PDCs of 20-80% and <20% had a 2.5-fold (95% CI: 1.0-6.7) respectively 4.0-fold (95% CI: 1.2-13.0) increased risk. Conclusion: There is a strong inverse relationship between adherence to GPAs and the risk of UGI complications in high-risk NSAID users.
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U2 - 10.1111/j.1365-2036.2007.03358.x
DO - 10.1111/j.1365-2036.2007.03358.x
M3 - Article
C2 - 17593072
AN - SCOPUS:34250814228
SN - 0269-2813
VL - 26
SP - 265
EP - 275
JO - Alimentary Pharmacology and Therapeutics
JF - Alimentary Pharmacology and Therapeutics
IS - 2
ER -