Advances in sarcoma genomics and therapeutic management

Nagavalli Somasundaram; Sock Hoai Chan; Richard Quek; Joanne Ngeow

doi:10.1016/B978-0-12-811785-9.00043-0

Advances in sarcoma genomics and therapeutic management

Nagavalli Somasundaram, Sock Hoai Chan, Richard Quek, Joanne Ngeow

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Sarcomas are rare mesenchymal malignancies arising in the soft tissues or bone that are known to be genetically diverse and notoriously difficult to treat. Advances in genomics fueled by massively parallel methods such as next-generation sequencing and array technologies have facilitated integrative analyses of genetic alterations with expression and clinical data, heralding opportunities for leveraging targeted therapies in the management of this challenging family of diseases. This chapter discusses how genomic progress has elevated understanding of the molecular mechanisms of sarcoma and its association with heritable cancer predisposition syndromes as well as the therapeutic implications consequent to this new knowledge.

Original language	English
Title of host publication	Oncogenomics
Subtitle of host publication	From Basic Research to Precision Medicine
Publisher	Elsevier
Pages	609-621
Number of pages	13
ISBN (Electronic)	9780128117859
ISBN (Print)	9780128117866
DOIs	https://doi.org/10.1016/B978-0-12-811785-9.00043-0
Publication status	Published - Jan 1 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc. All rights reserved.

ASJC Scopus Subject Areas

General Medicine

Keywords

Bone sarcoma
Cancer predisposition syndromes
Molecular genetics
Soft tissue sarcoma
Targeted therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-811785-9.00043-0

Cite this

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abstract = "Sarcomas are rare mesenchymal malignancies arising in the soft tissues or bone that are known to be genetically diverse and notoriously difficult to treat. Advances in genomics fueled by massively parallel methods such as next-generation sequencing and array technologies have facilitated integrative analyses of genetic alterations with expression and clinical data, heralding opportunities for leveraging targeted therapies in the management of this challenging family of diseases. This chapter discusses how genomic progress has elevated understanding of the molecular mechanisms of sarcoma and its association with heritable cancer predisposition syndromes as well as the therapeutic implications consequent to this new knowledge.",

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AU - Somasundaram, Nagavalli

AU - Chan, Sock Hoai

AU - Quek, Richard

AU - Ngeow, Joanne

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AB - Sarcomas are rare mesenchymal malignancies arising in the soft tissues or bone that are known to be genetically diverse and notoriously difficult to treat. Advances in genomics fueled by massively parallel methods such as next-generation sequencing and array technologies have facilitated integrative analyses of genetic alterations with expression and clinical data, heralding opportunities for leveraging targeted therapies in the management of this challenging family of diseases. This chapter discusses how genomic progress has elevated understanding of the molecular mechanisms of sarcoma and its association with heritable cancer predisposition syndromes as well as the therapeutic implications consequent to this new knowledge.

KW - Bone sarcoma

KW - Cancer predisposition syndromes

KW - Molecular genetics

KW - Soft tissue sarcoma

KW - Targeted therapy

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M3 - Chapter

AN - SCOPUS:85081366329

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EP - 621

BT - Oncogenomics

PB - Elsevier

ER -

Advances in sarcoma genomics and therapeutic management

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

UN SDGs

Access to Document

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