Advances in zinc finger engineering

Yen Choo; Mark Isalan

doi:10.1016/S0959-440X(00)00107-X

Advances in zinc finger engineering

Yen Choo^*, Mark Isalan

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

86 Citations (Scopus)

Abstract

Recently developments have been made in engineering sequence-specific zinc finger DNA-binding proteins. Advances in this area will soon make it routine to target proteins to specific DNA sequences associated with any given gene. The primary interest is in the regulation of gene expression using customised transcription factors. However, modular catalytic domains are also being developed in order to engineer chimaeric proteins with customised restriction enzyme, methylase and integrase activity.

Original language	English
Pages (from-to)	411-416
Number of pages	6
Journal	Current Opinion in Structural Biology
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/S0959-440X(00)00107-X
Publication status	Published - Aug 1 2000
Externally published	Yes

ASJC Scopus Subject Areas

Structural Biology
Molecular Biology

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10.1016/S0959-440X(00)00107-X

Cite this

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Advances in zinc finger engineering

Abstract

ASJC Scopus Subject Areas

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