Abstract
Aims: Continuous nanostructures embedded with proteins may synergistically present topographical and biochemical signals to cells for tissue engineering applications. This study presents the co-axial electrospinning of aligned poly(e-caprolactone) nanofibers encapsulated with bovine serum albumin and platelet-derived growth factor-bb for demonstration of controlled release and bioactivity retention, respectively. Materials & methods: Controllable release kinetics is achieved by incorporation of Polyethylene glycol) as a porogen in the shell of the nanofibers. Results & discussion: Polyethylene glycol) leaches out in a concentration- and molecular weight-dependent fashion, leading to bovine serum albumin release half-lives that range from 1 to 20 days. Optimized platelet-derived growth factor-bb-encapsulated nanofibers can completely release the protein with near zero-order kinetics and preserved bioactivity. Conclusion: Co-axial electrospinning is shown to be a versatile technique in achieving the delivery of biochemical signals in a controlled manner for regenerative medicine applications.
| Original language | English |
|---|---|
| Pages (from-to) | 465-471 |
| Number of pages | 7 |
| Journal | Nanomedicine |
| Volume | 1 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Dec 2006 |
| Externally published | Yes |
ASJC Scopus Subject Areas
- Bioengineering
- Medicine (miscellaneous)
- Biomedical Engineering
- General Materials Science
- Development
Keywords
- Co-axial electrospinning
- Electrospinning
- Fibrous scaffold
- Nanofibers
- Protein delivery
- Tissue engineering