All wrapped up

Yen Choo; John W.R. Schwabe

doi:10.1038/nsb0498-253

All wrapped up

Yen Choo^*, John W.R. Schwabe

^*Corresponding author for this work

Medical Research Council

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

Abstract

How is it possible that nine small repeated 'zinc finger' units (each spanning just 3 or 4 base pairs) can protect the whole 50 base pair binding site of TFIIIA and why should such a periodic protein structure give rise to such an asymmetric footprint on DNA? The crystal structure of the first six fingers of TFIIIA bound to 31 base pairs of DNA explains everything: not all zinc fingers act alike.

Original language	English
Pages (from-to)	253-255
Number of pages	3
Journal	Nature Structural Biology
Volume	5
Issue number	4
DOIs	https://doi.org/10.1038/nsb0498-253
Publication status	Published - Apr 1998
Externally published	Yes

ASJC Scopus Subject Areas

Structural Biology
Biochemistry
Genetics

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10.1038/nsb0498-253

Cite this

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abstract = "How is it possible that nine small repeated 'zinc finger' units (each spanning just 3 or 4 base pairs) can protect the whole 50 base pair binding site of TFIIIA and why should such a periodic protein structure give rise to such an asymmetric footprint on DNA? The crystal structure of the first six fingers of TFIIIA bound to 31 base pairs of DNA explains everything: not all zinc fingers act alike.",

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AB - How is it possible that nine small repeated 'zinc finger' units (each spanning just 3 or 4 base pairs) can protect the whole 50 base pair binding site of TFIIIA and why should such a periodic protein structure give rise to such an asymmetric footprint on DNA? The crystal structure of the first six fingers of TFIIIA bound to 31 base pairs of DNA explains everything: not all zinc fingers act alike.

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All wrapped up

Abstract

ASJC Scopus Subject Areas

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