Allylation of Lactol in Water

Mengxue Zheng; Wenxiu Gao; Lei Zhang; Kaiyu Yan; Zhenguo Zhang; Peizhong Xie; Teck Peng Loh

doi:10.1021/acs.orglett.4c04189

Allylation of Lactol in Water

Mengxue Zheng, Wenxiu Gao, Lei Zhang^*, Kaiyu Yan, Zhenguo Zhang, Peizhong Xie^*, Teck Peng Loh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3H)-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.

Original language	English
Journal	Organic Letters
DOIs	https://doi.org/10.1021/acs.orglett.4c04189
Publication status	Accepted/In press - 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2024 American Chemical Society.

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.4c04189

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title = "Allylation of Lactol in Water",

abstract = "We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3H)-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.",

author = "Mengxue Zheng and Wenxiu Gao and Lei Zhang and Kaiyu Yan and Zhenguo Zhang and Peizhong Xie and Loh, {Teck Peng}",

note = "Publisher Copyright: {\textcopyright} 2024 American Chemical Society.",

year = "2024",

doi = "10.1021/acs.orglett.4c04189",

language = "English",

journal = "Organic Letters",

issn = "1523-7060",

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T1 - Allylation of Lactol in Water

AU - Zheng, Mengxue

AU - Gao, Wenxiu

AU - Zhang, Lei

AU - Yan, Kaiyu

AU - Zhang, Zhenguo

AU - Xie, Peizhong

AU - Loh, Teck Peng

PY - 2024

Y1 - 2024

N2 - We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3H)-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.

AB - We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3H)-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.

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U2 - 10.1021/acs.orglett.4c04189

DO - 10.1021/acs.orglett.4c04189

M3 - Article

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SN - 1523-7060

JO - Organic Letters

JF - Organic Letters

ER -

Allylation of Lactol in Water

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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