Amide-Directed C−H Sodiation by a Sodium Hydride/Iodide Composite

Yinhua Huang; Guo Hao Chan; Shunsuke Chiba

doi:10.1002/anie.201702512

Amide-Directed C−H Sodiation by a Sodium Hydride/Iodide Composite

Yinhua Huang, Guo Hao Chan, Shunsuke Chiba^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

A new protocol for amide-directed ortho and lateral C−H sodiation is enabled by sodium hydride (NaH) in the presence of either sodium iodide (NaI) or lithium iodide (LiI). The transient organosodium intermediates could be transformed into functionalized aromatic compounds.

Original language	English
Pages (from-to)	6544-6547
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	56
Issue number	23
DOIs	https://doi.org/10.1002/anie.201702512
Publication status	Published - Jun 1 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

ASJC Scopus Subject Areas

Catalysis
General Chemistry

Keywords

amides
arenes
C−H activation
metalation
sodium hydride

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10.1002/anie.201702512

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abstract = "A new protocol for amide-directed ortho and lateral C−H sodiation is enabled by sodium hydride (NaH) in the presence of either sodium iodide (NaI) or lithium iodide (LiI). The transient organosodium intermediates could be transformed into functionalized aromatic compounds.",

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AB - A new protocol for amide-directed ortho and lateral C−H sodiation is enabled by sodium hydride (NaH) in the presence of either sodium iodide (NaI) or lithium iodide (LiI). The transient organosodium intermediates could be transformed into functionalized aromatic compounds.

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KW - C−H activation

KW - metalation

KW - sodium hydride

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Amide-Directed C−H Sodiation by a Sodium Hydride/Iodide Composite

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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