An asymmetric synthesis of the polyol fragment of the polyene macrolide antibiotic RK-397

Fan Fu; Teck Peng Loh

doi:10.1016/j.tetlet.2009.03.019

An asymmetric synthesis of the polyol fragment of the polyene macrolide antibiotic RK-397

Fan Fu, Teck Peng Loh^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A highly convergent and asymmetric synthesis of the C11-C31 polyol fragment of RK-397 as a single isomer is accomplished via a catalytic enantioselective hetero-Diels-Alder reaction and an intermolecular olefin cross-metathesis as key steps.

Original language	English
Pages (from-to)	3530-3533
Number of pages	4
Journal	Tetrahedron Letters
Volume	50
Issue number	26
DOIs	https://doi.org/10.1016/j.tetlet.2009.03.019
Publication status	Published - Jul 1 2009
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2009.03.019

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title = "An asymmetric synthesis of the polyol fragment of the polyene macrolide antibiotic RK-397",

abstract = "A highly convergent and asymmetric synthesis of the C11-C31 polyol fragment of RK-397 as a single isomer is accomplished via a catalytic enantioselective hetero-Diels-Alder reaction and an intermolecular olefin cross-metathesis as key steps.",

author = "Fan Fu and Loh, {Teck Peng}",

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AU - Loh, Teck Peng

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AB - A highly convergent and asymmetric synthesis of the C11-C31 polyol fragment of RK-397 as a single isomer is accomplished via a catalytic enantioselective hetero-Diels-Alder reaction and an intermolecular olefin cross-metathesis as key steps.

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M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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An asymmetric synthesis of the polyol fragment of the polyene macrolide antibiotic RK-397

Abstract

ASJC Scopus Subject Areas

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