An efficient method for the synthesis of 2-pyridones: Via C-H bond functionalization

Shuguang Zhou; Duan Yang Liu; Suo Wang; Jie Sheng Tian; Teck Peng Loh

doi:10.1039/d0cc06834a

An efficient method for the synthesis of 2-pyridones: Via C-H bond functionalization

Shuguang Zhou, Duan Yang Liu, Suo Wang, Jie Sheng Tian^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A simple and practical method to access N-substituted 2-pyridones via a formal [3+3] annulation of enaminones with acrylates based on RhIII-catalyzed C-H functionalization was developed. Control and deuterated experiments led to a plausible mechanism involving C-H bond cross-coupling and aminolysis cyclization. This strategy provides a short synthesis of structural motifs of N-substituted 2-pyridones.

Original language	English
Pages (from-to)	15020-15023
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	95
DOIs	https://doi.org/10.1039/d0cc06834a
Publication status	Published - Dec 11 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "A simple and practical method to access N-substituted 2-pyridones via a formal [3+3] annulation of enaminones with acrylates based on RhIII-catalyzed C-H functionalization was developed. Control and deuterated experiments led to a plausible mechanism involving C-H bond cross-coupling and aminolysis cyclization. This strategy provides a short synthesis of structural motifs of N-substituted 2-pyridones.",

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AU - Wang, Suo

AU - Tian, Jie Sheng

AU - Loh, Teck Peng

PY - 2020/12/11

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An efficient method for the synthesis of 2-pyridones: Via C-H bond functionalization

Abstract

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ASJC Scopus Subject Areas

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