Analysis of EIF4G1 in Parkinson's disease among Asians

Yi Zhao; Patrick Ho; Kumar M. Prakash; Jia Nee Foo; Jian Jun Liu; Wing Lok Au; Louis C. Tan; Eng King Tan

doi:10.1016/j.neurobiolaging.2012.09.003

Analysis of EIF4G1 in Parkinson's disease among Asians

Yi Zhao, Patrick Ho, Kumar M. Prakash, Jia Nee Foo, Jian Jun Liu, Wing Lok Au, Louis C. Tan, Eng King Tan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Sequence analysis of all the exons of EIF4G1 in 96 Asian patients with Parkinson's disease (PD) did not reveal any pathogenic mutations. A novel coding variant (Pro693Ser) in exon 15 (position 2077) was detected in one PD patient but not in 539 control subjects. Analysis of a coding polymorphic variant (rs2178403) in 1330 subjects revealed similar frequency between control subjects (0.638) and PD patients (0.640). EIF4G1 is an uncommon cause of PD in our Asian cohort.

Original language	English
Pages (from-to)	1311.e5-1311.e6
Journal	Neurobiology of Aging
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.neurobiolaging.2012.09.003
Publication status	Published - Apr 2013
Externally published	Yes

ASJC Scopus Subject Areas

General Neuroscience
Ageing
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

Keywords

Gene
Parkinson's disease

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10.1016/j.neurobiolaging.2012.09.003

Cite this

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title = "Analysis of EIF4G1 in Parkinson's disease among Asians",

abstract = "Sequence analysis of all the exons of EIF4G1 in 96 Asian patients with Parkinson's disease (PD) did not reveal any pathogenic mutations. A novel coding variant (Pro693Ser) in exon 15 (position 2077) was detected in one PD patient but not in 539 control subjects. Analysis of a coding polymorphic variant (rs2178403) in 1330 subjects revealed similar frequency between control subjects (0.638) and PD patients (0.640). EIF4G1 is an uncommon cause of PD in our Asian cohort.",

keywords = "Gene, Parkinson's disease",

author = "Yi Zhao and Patrick Ho and Prakash, {Kumar M.} and Foo, {Jia Nee} and Liu, {Jian Jun} and Au, {Wing Lok} and Tan, {Louis C.} and Tan, {Eng King}",

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doi = "10.1016/j.neurobiolaging.2012.09.003",

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journal = "Neurobiology of Aging",

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AU - Zhao, Yi

AU - Ho, Patrick

AU - Prakash, Kumar M.

AU - Foo, Jia Nee

AU - Liu, Jian Jun

AU - Au, Wing Lok

AU - Tan, Louis C.

AU - Tan, Eng King

PY - 2013/4

Y1 - 2013/4

N2 - Sequence analysis of all the exons of EIF4G1 in 96 Asian patients with Parkinson's disease (PD) did not reveal any pathogenic mutations. A novel coding variant (Pro693Ser) in exon 15 (position 2077) was detected in one PD patient but not in 539 control subjects. Analysis of a coding polymorphic variant (rs2178403) in 1330 subjects revealed similar frequency between control subjects (0.638) and PD patients (0.640). EIF4G1 is an uncommon cause of PD in our Asian cohort.

AB - Sequence analysis of all the exons of EIF4G1 in 96 Asian patients with Parkinson's disease (PD) did not reveal any pathogenic mutations. A novel coding variant (Pro693Ser) in exon 15 (position 2077) was detected in one PD patient but not in 539 control subjects. Analysis of a coding polymorphic variant (rs2178403) in 1330 subjects revealed similar frequency between control subjects (0.638) and PD patients (0.640). EIF4G1 is an uncommon cause of PD in our Asian cohort.

KW - Gene

KW - Parkinson's disease

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DO - 10.1016/j.neurobiolaging.2012.09.003

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AN - SCOPUS:84872314762

SN - 0197-4580

VL - 34

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JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 4

ER -

Analysis of EIF4G1 in Parkinson's disease among Asians

Abstract

ASJC Scopus Subject Areas

Keywords

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