Antibiotic inhibitors of organellar protein synthesis in Plasmodium falciparum

Barbara Clough; Kaveri Rangachari; Malcolm Strath; Peter R. Preiser; R. J.M. Wilson

doi:10.1016/S1434-4610(99)70021-0

Antibiotic inhibitors of organellar protein synthesis in Plasmodium falciparum

Barbara Clough^*, Kaveri Rangachari, Malcolm Strath, Peter R. Preiser, R. J.M. Wilson

^*Corresponding author for this work

Medical Research Council

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

Elongation factor Tu (EF-Tu) is encoded by the tuf gene of the plastid organelle of the malaria parasite Plasmodium falciparum. A range of structurally unrelated inhibitors of this GTP-dependent translation factor was shown to have antimalarial activity in blood cultures. The most active was the cyclic thiazolyl peptide amythiamicin A with an IC⁵⁰ = 0.01 μM. Demonstrable complexes were formed in vitro between a recombinant version of P. falciparum EF-Tu(pl) and inhibitors that bind to different sites on EF-Tu; these included the antibiotics kirromycin, GE2270A and enacyloxin IIa.

Original language	English
Pages (from-to)	189-195
Number of pages	7
Journal	Protist
Volume	150
Issue number	2
DOIs	https://doi.org/10.1016/S1434-4610(99)70021-0
Publication status	Published - Aug 1999
Externally published	Yes

ASJC Scopus Subject Areas

Microbiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S1434-4610(99)70021-0

Cite this

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AU - Wilson, R. J.M.

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Antibiotic inhibitors of organellar protein synthesis in Plasmodium falciparum

Abstract

ASJC Scopus Subject Areas

UN SDGs

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