Abstract
Elongation factor Tu (EF-Tu) is encoded by the tuf gene of the plastid organelle of the malaria parasite Plasmodium falciparum. A range of structurally unrelated inhibitors of this GTP-dependent translation factor was shown to have antimalarial activity in blood cultures. The most active was the cyclic thiazolyl peptide amythiamicin A with an IC50 = 0.01 μM. Demonstrable complexes were formed in vitro between a recombinant version of P. falciparum EF-Tu(pl) and inhibitors that bind to different sites on EF-Tu; these included the antibiotics kirromycin, GE2270A and enacyloxin IIa.
Original language | English |
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Pages (from-to) | 189-195 |
Number of pages | 7 |
Journal | Protist |
Volume | 150 |
Issue number | 2 |
DOIs | |
Publication status | Published - Aug 1999 |
Externally published | Yes |
ASJC Scopus Subject Areas
- Microbiology