Antibiotic inhibitors of organellar protein synthesis in Plasmodium falciparum

Barbara Clough*, Kaveri Rangachari, Malcolm Strath, Peter R. Preiser, R. J.M. Wilson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

Elongation factor Tu (EF-Tu) is encoded by the tuf gene of the plastid organelle of the malaria parasite Plasmodium falciparum. A range of structurally unrelated inhibitors of this GTP-dependent translation factor was shown to have antimalarial activity in blood cultures. The most active was the cyclic thiazolyl peptide amythiamicin A with an IC50 = 0.01 μM. Demonstrable complexes were formed in vitro between a recombinant version of P. falciparum EF-Tu(pl) and inhibitors that bind to different sites on EF-Tu; these included the antibiotics kirromycin, GE2270A and enacyloxin IIa.

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalProtist
Volume150
Issue number2
DOIs
Publication statusPublished - Aug 1999
Externally publishedYes

ASJC Scopus Subject Areas

  • Microbiology

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