Arsenene nanomotors as anticancer drug carrier

Nur Farhanah Rosli; Carmen C. Mayorga-Martinez; Adrian C. Fisher; Osamah Alduhaish; Richard D. Webster; Martin Pumera

doi:10.1016/j.apmt.2020.100819

Arsenene nanomotors as anticancer drug carrier

Nur Farhanah Rosli, Carmen C. Mayorga-Martinez^*, Adrian C. Fisher, Osamah Alduhaish, Richard D. Webster, Martin Pumera

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Nanotechnology has allowed rapid advancements in nanomachines for variety of biomedical applications, including drug delivery, due to their loading and transporting capabilities. Utilizing pnictogen, such as arsenic, antimony and bismuth, as nanomachines for biomedical applications are still in infancy. Herein, template-less arsenene-based Janus nanomachines with layered structure which allowed high loading capacity are explored by specifically modifying arsenene nanoparticles with platinum, forming As-Pt nanomotors. Their motion capabilities, biocompatibility and drug loading competency were thoroughly investigated. The results showed fast, biocompatible, high drug loading and high cellular uptake of As-Pt nanomotors. These findings open new direction in arsenene nanoparticles as nontoxic self-propelled drug carrier applications.

Original language	English
Article number	100819
Journal	Applied Materials Today
Volume	21
DOIs	https://doi.org/10.1016/j.apmt.2020.100819
Publication status	Published - Dec 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020

ASJC Scopus Subject Areas

General Materials Science

Keywords

Doxorubicin
Micromotors
Nanomaterials
Pnictogen
Toxicity

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10.1016/j.apmt.2020.100819

Cite this

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title = "Arsenene nanomotors as anticancer drug carrier",

abstract = "Nanotechnology has allowed rapid advancements in nanomachines for variety of biomedical applications, including drug delivery, due to their loading and transporting capabilities. Utilizing pnictogen, such as arsenic, antimony and bismuth, as nanomachines for biomedical applications are still in infancy. Herein, template-less arsenene-based Janus nanomachines with layered structure which allowed high loading capacity are explored by specifically modifying arsenene nanoparticles with platinum, forming As-Pt nanomotors. Their motion capabilities, biocompatibility and drug loading competency were thoroughly investigated. The results showed fast, biocompatible, high drug loading and high cellular uptake of As-Pt nanomotors. These findings open new direction in arsenene nanoparticles as nontoxic self-propelled drug carrier applications.",

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AU - Rosli, Nur Farhanah

AU - Mayorga-Martinez, Carmen C.

AU - Fisher, Adrian C.

AU - Alduhaish, Osamah

AU - Webster, Richard D.

AU - Pumera, Martin

PY - 2020/12

Y1 - 2020/12

N2 - Nanotechnology has allowed rapid advancements in nanomachines for variety of biomedical applications, including drug delivery, due to their loading and transporting capabilities. Utilizing pnictogen, such as arsenic, antimony and bismuth, as nanomachines for biomedical applications are still in infancy. Herein, template-less arsenene-based Janus nanomachines with layered structure which allowed high loading capacity are explored by specifically modifying arsenene nanoparticles with platinum, forming As-Pt nanomotors. Their motion capabilities, biocompatibility and drug loading competency were thoroughly investigated. The results showed fast, biocompatible, high drug loading and high cellular uptake of As-Pt nanomotors. These findings open new direction in arsenene nanoparticles as nontoxic self-propelled drug carrier applications.

AB - Nanotechnology has allowed rapid advancements in nanomachines for variety of biomedical applications, including drug delivery, due to their loading and transporting capabilities. Utilizing pnictogen, such as arsenic, antimony and bismuth, as nanomachines for biomedical applications are still in infancy. Herein, template-less arsenene-based Janus nanomachines with layered structure which allowed high loading capacity are explored by specifically modifying arsenene nanoparticles with platinum, forming As-Pt nanomotors. Their motion capabilities, biocompatibility and drug loading competency were thoroughly investigated. The results showed fast, biocompatible, high drug loading and high cellular uptake of As-Pt nanomotors. These findings open new direction in arsenene nanoparticles as nontoxic self-propelled drug carrier applications.

KW - Doxorubicin

KW - Micromotors

KW - Nanomaterials

KW - Pnictogen

KW - Toxicity

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Arsenene nanomotors as anticancer drug carrier

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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