Asymmetric synthesis of C-aliphatic homoallylic amines and biologically important cyclohexenylamine analogues

Chi Lik Ken Lee; Hui Yvonne Ling; Teck Peng Loh

doi:10.1021/jo048903o

Asymmetric synthesis of C-aliphatic homoallylic amines and biologically important cyclohexenylamine analogues

Chi Lik Ken Lee, Hui Yvonne Ling, Teck Peng Loh^*

^*Corresponding author for this work

National University of Singapore

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

An efficient method for the asymmetric synthesis of C-aliphatic homoallylic amines with up to 94% yield and 80% de is reported. Ring-closing metathesis of several chiral homoallylic amines using the second-generation Grubbs catalyst provided easy access to a wide variety of cyclohexenylamines.

Original language	English
Pages (from-to)	7787-7789
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	69
Issue number	22
DOIs	https://doi.org/10.1021/jo048903o
Publication status	Published - Oct 29 2004
Externally published	Yes

ASJC Scopus Subject Areas

Organic Chemistry

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title = "Asymmetric synthesis of C-aliphatic homoallylic amines and biologically important cyclohexenylamine analogues",

abstract = "An efficient method for the asymmetric synthesis of C-aliphatic homoallylic amines with up to 94% yield and 80% de is reported. Ring-closing metathesis of several chiral homoallylic amines using the second-generation Grubbs catalyst provided easy access to a wide variety of cyclohexenylamines.",

author = "Lee, {Chi Lik Ken} and Ling, {Hui Yvonne} and Loh, {Teck Peng}",

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AU - Lee, Chi Lik Ken

AU - Ling, Hui Yvonne

AU - Loh, Teck Peng

PY - 2004/10/29

Y1 - 2004/10/29

N2 - An efficient method for the asymmetric synthesis of C-aliphatic homoallylic amines with up to 94% yield and 80% de is reported. Ring-closing metathesis of several chiral homoallylic amines using the second-generation Grubbs catalyst provided easy access to a wide variety of cyclohexenylamines.

AB - An efficient method for the asymmetric synthesis of C-aliphatic homoallylic amines with up to 94% yield and 80% de is reported. Ring-closing metathesis of several chiral homoallylic amines using the second-generation Grubbs catalyst provided easy access to a wide variety of cyclohexenylamines.

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JO - Journal of Organic Chemistry

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Asymmetric synthesis of C-aliphatic homoallylic amines and biologically important cyclohexenylamine analogues

Abstract

ASJC Scopus Subject Areas

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