Atypical K6-ubiquitin chains mobilize p97/VCP and the proteasome to resolve formaldehyde-induced RNA-protein crosslinks

Wei Song; Kristijan Ramadan

doi:10.1016/j.molcel.2023.11.009

Atypical K6-ubiquitin chains mobilize p97/VCP and the proteasome to resolve formaldehyde-induced RNA-protein crosslinks

Wei Song, Kristijan Ramadan^*

^*Corresponding author for this work

University of Oxford

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

In this issue of Molecular Cell, Rahmanto et al.¹ and Zhao et al.² demonstrate that RNA-protein crosslinks contribute to formaldehyde toxicity by blocking protein synthesis. Furthermore, they identify a ubiquitin-mediated degradation system for RNA-protein crosslink resolution in eukaryotes.

Original language	English
Pages (from-to)	4197-4199
Number of pages	3
Journal	Molecular Cell
Volume	83
Issue number	23
DOIs	https://doi.org/10.1016/j.molcel.2023.11.009
Publication status	Published - Dec 7 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Inc.

ASJC Scopus Subject Areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2023.11.009

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title = "Atypical K6-ubiquitin chains mobilize p97/VCP and the proteasome to resolve formaldehyde-induced RNA-protein crosslinks",

abstract = "In this issue of Molecular Cell, Rahmanto et al.1 and Zhao et al.2 demonstrate that RNA-protein crosslinks contribute to formaldehyde toxicity by blocking protein synthesis. Furthermore, they identify a ubiquitin-mediated degradation system for RNA-protein crosslink resolution in eukaryotes.",

author = "Wei Song and Kristijan Ramadan",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

month = dec,

day = "7",

doi = "10.1016/j.molcel.2023.11.009",

language = "English",

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AU - Song, Wei

AU - Ramadan, Kristijan

PY - 2023/12/7

Y1 - 2023/12/7

N2 - In this issue of Molecular Cell, Rahmanto et al.1 and Zhao et al.2 demonstrate that RNA-protein crosslinks contribute to formaldehyde toxicity by blocking protein synthesis. Furthermore, they identify a ubiquitin-mediated degradation system for RNA-protein crosslink resolution in eukaryotes.

AB - In this issue of Molecular Cell, Rahmanto et al.1 and Zhao et al.2 demonstrate that RNA-protein crosslinks contribute to formaldehyde toxicity by blocking protein synthesis. Furthermore, they identify a ubiquitin-mediated degradation system for RNA-protein crosslink resolution in eukaryotes.

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U2 - 10.1016/j.molcel.2023.11.009

DO - 10.1016/j.molcel.2023.11.009

M3 - Comment/debate

C2 - 38065058

AN - SCOPUS:85178146190

SN - 1097-2765

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JO - Molecular Cell

JF - Molecular Cell

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Atypical K6-ubiquitin chains mobilize p97/VCP and the proteasome to resolve formaldehyde-induced RNA-protein crosslinks

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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