Bacterial cellulose adhesive composites for oral cavity applications

Juhi Singh; Nigel C.S. Tan; Usha Rani Mahadevaswamy; Nattharee Chanchareonsook; Terry W.J. Steele; Sierin Lim

doi:10.1016/j.carbpol.2021.118403

Bacterial cellulose adhesive composites for oral cavity applications

Juhi Singh, Nigel C.S. Tan, Usha Rani Mahadevaswamy, Nattharee Chanchareonsook, Terry W.J. Steele^*, Sierin Lim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Topical approaches to oral diseases require frequent dosing due to limited retention time. A mucoadhesive drug delivery platform with extended soft tissue adhesion capability of up to 7 days is proposed for on-site management of oral wound. Bacterial cellulose (BC) and photoactivated carbene-based bioadhesives (PDz) are combined to yield flexible film platform for interfacing soft tissues in dynamic, wet environments. Structure-activity relationships evaluate UV dose and hydration state with respect to adhesive strength on soft tissue mimics. The bioadhesive composite has an adhesion strength ranging from 7 to 17 kPa and duration exceeding 48 h in wet conditions under sustained shear forces, while other mucoadhesives based on hydrophilic macromolecules exhibit adhesion strength of 0.5–5 kPa and last only a few hours. The work highlights the first evaluation of BC composites for mucoadhesive treatments in the buccal cavity.

Original language	English
Article number	118403
Journal	Carbohydrate Polymers
Volume	274
DOIs	https://doi.org/10.1016/j.carbpol.2021.118403
Publication status	Published - Nov 15 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021

ASJC Scopus Subject Areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

Keywords

Bacterial cellulose
BC
Bioadhesives
Mucoadhesives
Oral patch
Photocuring

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10.1016/j.carbpol.2021.118403

Cite this

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title = "Bacterial cellulose adhesive composites for oral cavity applications",

abstract = "Topical approaches to oral diseases require frequent dosing due to limited retention time. A mucoadhesive drug delivery platform with extended soft tissue adhesion capability of up to 7 days is proposed for on-site management of oral wound. Bacterial cellulose (BC) and photoactivated carbene-based bioadhesives (PDz) are combined to yield flexible film platform for interfacing soft tissues in dynamic, wet environments. Structure-activity relationships evaluate UV dose and hydration state with respect to adhesive strength on soft tissue mimics. The bioadhesive composite has an adhesion strength ranging from 7 to 17 kPa and duration exceeding 48 h in wet conditions under sustained shear forces, while other mucoadhesives based on hydrophilic macromolecules exhibit adhesion strength of 0.5–5 kPa and last only a few hours. The work highlights the first evaluation of BC composites for mucoadhesive treatments in the buccal cavity.",

keywords = "Bacterial cellulose, BC, Bioadhesives, Mucoadhesives, Oral patch, Photocuring",

author = "Juhi Singh and Tan, {Nigel C.S.} and Mahadevaswamy, {Usha Rani} and Nattharee Chanchareonsook and Steele, {Terry W.J.} and Sierin Lim",

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month = nov,

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doi = "10.1016/j.carbpol.2021.118403",

language = "English",

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journal = "Carbohydrate Polymers",

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AU - Singh, Juhi

AU - Tan, Nigel C.S.

AU - Mahadevaswamy, Usha Rani

AU - Chanchareonsook, Nattharee

AU - Steele, Terry W.J.

AU - Lim, Sierin

PY - 2021/11/15

Y1 - 2021/11/15

N2 - Topical approaches to oral diseases require frequent dosing due to limited retention time. A mucoadhesive drug delivery platform with extended soft tissue adhesion capability of up to 7 days is proposed for on-site management of oral wound. Bacterial cellulose (BC) and photoactivated carbene-based bioadhesives (PDz) are combined to yield flexible film platform for interfacing soft tissues in dynamic, wet environments. Structure-activity relationships evaluate UV dose and hydration state with respect to adhesive strength on soft tissue mimics. The bioadhesive composite has an adhesion strength ranging from 7 to 17 kPa and duration exceeding 48 h in wet conditions under sustained shear forces, while other mucoadhesives based on hydrophilic macromolecules exhibit adhesion strength of 0.5–5 kPa and last only a few hours. The work highlights the first evaluation of BC composites for mucoadhesive treatments in the buccal cavity.

AB - Topical approaches to oral diseases require frequent dosing due to limited retention time. A mucoadhesive drug delivery platform with extended soft tissue adhesion capability of up to 7 days is proposed for on-site management of oral wound. Bacterial cellulose (BC) and photoactivated carbene-based bioadhesives (PDz) are combined to yield flexible film platform for interfacing soft tissues in dynamic, wet environments. Structure-activity relationships evaluate UV dose and hydration state with respect to adhesive strength on soft tissue mimics. The bioadhesive composite has an adhesion strength ranging from 7 to 17 kPa and duration exceeding 48 h in wet conditions under sustained shear forces, while other mucoadhesives based on hydrophilic macromolecules exhibit adhesion strength of 0.5–5 kPa and last only a few hours. The work highlights the first evaluation of BC composites for mucoadhesive treatments in the buccal cavity.

KW - Bacterial cellulose

KW - BC

KW - Bioadhesives

KW - Mucoadhesives

KW - Oral patch

KW - Photocuring

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JO - Carbohydrate Polymers

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M1 - 118403

ER -

Bacterial cellulose adhesive composites for oral cavity applications

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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