Bio-inspired micropatterned platform to steer stem cell differentiation

Chor Yong Tay; Mintu Pal; Haiyang Yu; Wen Shing Leong; Nguan Soon Tan; Kee Woei Ng; Subbu Venkatraman; Freddy Boey; David Tai Leong; Lay Poh Tan

doi:10.1002/smll.201002298

Bio-inspired micropatterned platform to steer stem cell differentiation

Chor Yong Tay, Mintu Pal, Haiyang Yu, Wen Shing Leong, Nguan Soon Tan, Kee Woei Ng, Subbu Venkatraman, Freddy Boey, David Tai Leong, Lay Poh Tan

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Controlled stem cell differentiation on micropatterned biodegradable substrates involves modulation of the canonical FAK-ERK (focal adhesion kinase-extracellular-signal regulated kinase) signaling pathway in the absence of exogenous soluble factors. The use of a micropatterned platform to coerce human mesenchymal stem cells to adopt an elongated morphology bypasses the need to use pharmacological factors to repress FAK-ERK signaling activity to bring about substantial myogenesis.

Original language	English
Pages (from-to)	1416-1421
Number of pages	6
Journal	Small
Volume	7
Issue number	10
DOIs	https://doi.org/10.1002/smll.201002298
Publication status	Published - May 23 2011
Externally published	Yes

ASJC Scopus Subject Areas

Biotechnology
Biomaterials
General Chemistry
General Materials Science

Keywords

biomaterials
biomimetics
microcontact printing
micropatterning
stem cells

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10.1002/smll.201002298

Cite this

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title = "Bio-inspired micropatterned platform to steer stem cell differentiation",

abstract = "Controlled stem cell differentiation on micropatterned biodegradable substrates involves modulation of the canonical FAK-ERK (focal adhesion kinase-extracellular-signal regulated kinase) signaling pathway in the absence of exogenous soluble factors. The use of a micropatterned platform to coerce human mesenchymal stem cells to adopt an elongated morphology bypasses the need to use pharmacological factors to repress FAK-ERK signaling activity to bring about substantial myogenesis.",

keywords = "biomaterials, biomimetics, microcontact printing, micropatterning, stem cells",

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year = "2011",

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doi = "10.1002/smll.201002298",

language = "English",

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AU - Tay, Chor Yong

AU - Pal, Mintu

AU - Yu, Haiyang

AU - Leong, Wen Shing

AU - Tan, Nguan Soon

AU - Ng, Kee Woei

AU - Venkatraman, Subbu

AU - Boey, Freddy

AU - Leong, David Tai

AU - Tan, Lay Poh

PY - 2011/5/23

Y1 - 2011/5/23

N2 - Controlled stem cell differentiation on micropatterned biodegradable substrates involves modulation of the canonical FAK-ERK (focal adhesion kinase-extracellular-signal regulated kinase) signaling pathway in the absence of exogenous soluble factors. The use of a micropatterned platform to coerce human mesenchymal stem cells to adopt an elongated morphology bypasses the need to use pharmacological factors to repress FAK-ERK signaling activity to bring about substantial myogenesis.

AB - Controlled stem cell differentiation on micropatterned biodegradable substrates involves modulation of the canonical FAK-ERK (focal adhesion kinase-extracellular-signal regulated kinase) signaling pathway in the absence of exogenous soluble factors. The use of a micropatterned platform to coerce human mesenchymal stem cells to adopt an elongated morphology bypasses the need to use pharmacological factors to repress FAK-ERK signaling activity to bring about substantial myogenesis.

KW - biomaterials

KW - biomimetics

KW - microcontact printing

KW - micropatterning

KW - stem cells

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JF - Small

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ER -

Bio-inspired micropatterned platform to steer stem cell differentiation

Abstract

ASJC Scopus Subject Areas

Keywords

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