Biocompatible C-S bond construction for diarylmethyl thioethers

Zhenwei Zhang; Xu Tao; Chengyang Ju; Cuiqing Gao; Teck Peng Loh; Peizhong Xie

doi:10.1016/j.gresc.2025.03.002

Biocompatible C-S bond construction for diarylmethyl thioethers

Zhenwei Zhang, Xu Tao, Chengyang Ju, Cuiqing Gao, Teck Peng Loh^*, Peizhong Xie

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We have developed a sustainable method for the construction of C-S bonds, in line with green chemistry principles, and modifiable for thiol-specific conjugation. Selecting p-quinone methides (p-QMs) as partners, this methodology allows efficient preparation of diarylmethyl thioethers with broad thiol compatibility, exceptional chemo-selectivity, and stability. This process facilitates the large-scale preparation of diarylmethyl thioethers, and also enhances applications in bioconjugation, providing valuable tools for drug development and biomolecular engineering.

Original language	English
Journal	Green Synthesis and Catalysis
DOIs	https://doi.org/10.1016/j.gresc.2025.03.002
Publication status	Accepted/In press - 2025
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2025 Fudan University

ASJC Scopus Subject Areas

Biotechnology
Catalysis

Keywords

Biocompatible conditions
Bioconjugation
C-S bond construction
Diarylmethyl thioethers

Access to Document

10.1016/j.gresc.2025.03.002

Cite this

@article{62204ebcd4354107b52c11eec7bad8fa,

title = "Biocompatible C-S bond construction for diarylmethyl thioethers",

abstract = "We have developed a sustainable method for the construction of C-S bonds, in line with green chemistry principles, and modifiable for thiol-specific conjugation. Selecting p-quinone methides (p-QMs) as partners, this methodology allows efficient preparation of diarylmethyl thioethers with broad thiol compatibility, exceptional chemo-selectivity, and stability. This process facilitates the large-scale preparation of diarylmethyl thioethers, and also enhances applications in bioconjugation, providing valuable tools for drug development and biomolecular engineering.",

keywords = "Biocompatible conditions, Bioconjugation, C-S bond construction, Diarylmethyl thioethers",

author = "Zhenwei Zhang and Xu Tao and Chengyang Ju and Cuiqing Gao and Loh, {Teck Peng} and Peizhong Xie",

note = "Publisher Copyright: {\textcopyright} 2025 Fudan University",

year = "2025",

doi = "10.1016/j.gresc.2025.03.002",

language = "English",

journal = "Green Synthesis and Catalysis",

issn = "2666-5549",

}

TY - JOUR

T1 - Biocompatible C-S bond construction for diarylmethyl thioethers

AU - Zhang, Zhenwei

AU - Tao, Xu

AU - Ju, Chengyang

AU - Gao, Cuiqing

AU - Loh, Teck Peng

AU - Xie, Peizhong

PY - 2025

Y1 - 2025

N2 - We have developed a sustainable method for the construction of C-S bonds, in line with green chemistry principles, and modifiable for thiol-specific conjugation. Selecting p-quinone methides (p-QMs) as partners, this methodology allows efficient preparation of diarylmethyl thioethers with broad thiol compatibility, exceptional chemo-selectivity, and stability. This process facilitates the large-scale preparation of diarylmethyl thioethers, and also enhances applications in bioconjugation, providing valuable tools for drug development and biomolecular engineering.

AB - We have developed a sustainable method for the construction of C-S bonds, in line with green chemistry principles, and modifiable for thiol-specific conjugation. Selecting p-quinone methides (p-QMs) as partners, this methodology allows efficient preparation of diarylmethyl thioethers with broad thiol compatibility, exceptional chemo-selectivity, and stability. This process facilitates the large-scale preparation of diarylmethyl thioethers, and also enhances applications in bioconjugation, providing valuable tools for drug development and biomolecular engineering.

KW - Biocompatible conditions

KW - Bioconjugation

KW - C-S bond construction

KW - Diarylmethyl thioethers

UR - http://www.scopus.com/inward/record.url?scp=105000043992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=105000043992&partnerID=8YFLogxK

U2 - 10.1016/j.gresc.2025.03.002

DO - 10.1016/j.gresc.2025.03.002

M3 - Article

AN - SCOPUS:105000043992

SN - 2666-5549

JO - Green Synthesis and Catalysis

JF - Green Synthesis and Catalysis

ER -

Biocompatible C-S bond construction for diarylmethyl thioethers

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

Other files and links

Cite this