Bioinspired Deamination of α-Amino Acid Derivatives Catalyzed by a Palladium/Nickel Complex

Gongtao Deng; Jie Chen; Wangbin Sun; Kehan Bian; Yaojia Jiang; Teck Peng Loh

doi:10.1002/adsc.201800823

Bioinspired Deamination of α-Amino Acid Derivatives Catalyzed by a Palladium/Nickel Complex

Gongtao Deng, Jie Chen, Wangbin Sun, Kehan Bian, Yaojia Jiang^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

An efficient bioinspired deamination method of both natural and unnatural amino acid derivatives has been developed. This method provides easy access to a wide variety of useful α, β-unsaturated carbonyl compounds. The reaction is realized with two transition metal catalysts (palladium and Nickel) in-easy handling procedure. A possible reaction pathway is also proposed and the control experiments support the involvement of the palladium-catalyzed inert sp³ C−H activation as one of the key steps. (Figure presented.).

Original language	English
Pages (from-to)	3900-3905
Number of pages	6
Journal	Advanced Synthesis and Catalysis
Volume	360
Issue number	20
DOIs	https://doi.org/10.1002/adsc.201800823
Publication status	Published - Oct 18 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

ASJC Scopus Subject Areas

Catalysis
Organic Chemistry

Keywords

bioinspired reactions
C−H activation
deamination
synthetic methods

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10.1002/adsc.201800823

Cite this

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abstract = "An efficient bioinspired deamination method of both natural and unnatural amino acid derivatives has been developed. This method provides easy access to a wide variety of useful α, β-unsaturated carbonyl compounds. The reaction is realized with two transition metal catalysts (palladium and Nickel) in-easy handling procedure. A possible reaction pathway is also proposed and the control experiments support the involvement of the palladium-catalyzed inert sp3 C−H activation as one of the key steps. (Figure presented.).",

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AU - Deng, Gongtao

AU - Chen, Jie

AU - Sun, Wangbin

AU - Bian, Kehan

AU - Jiang, Yaojia

AU - Loh, Teck Peng

PY - 2018/10/18

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AB - An efficient bioinspired deamination method of both natural and unnatural amino acid derivatives has been developed. This method provides easy access to a wide variety of useful α, β-unsaturated carbonyl compounds. The reaction is realized with two transition metal catalysts (palladium and Nickel) in-easy handling procedure. A possible reaction pathway is also proposed and the control experiments support the involvement of the palladium-catalyzed inert sp3 C−H activation as one of the key steps. (Figure presented.).

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KW - synthetic methods

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Bioinspired Deamination of α-Amino Acid Derivatives Catalyzed by a Palladium/Nickel Complex

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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