Carbene-Catalyzed α-Carbon Amination of Chloroaldehydes for Enantioselective Access to Dihydroquinoxaline Derivatives

Ruoyan Huang; Xingkuan Chen; Chengli Mou; Guoyong Luo; Yongjia Li; Xiangyang Li; Wei Xue; Zhichao Jin; Yonggui Robin Chi

doi:10.1021/acs.orglett.9b01520

Carbene-Catalyzed α-Carbon Amination of Chloroaldehydes for Enantioselective Access to Dihydroquinoxaline Derivatives

Ruoyan Huang, Xingkuan Chen, Chengli Mou, Guoyong Luo, Yongjia Li, Xiangyang Li, Wei Xue^*, Zhichao Jin, Yonggui Robin Chi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

An NHC-catalyzed α-carbon amination of chloroaldehydes was developed. Cyclohexadiene-1,2-diimines are used as amination reagents and four-atom synthons. Our reaction affords optically enriched dihydroquinoxalines that are core structures in natural products and synthetic bioactive molecules.

Original language	English
Pages (from-to)	4340-4344
Number of pages	5
Journal	Organic Letters
Volume	21
Issue number	11
DOIs	https://doi.org/10.1021/acs.orglett.9b01520
Publication status	Published - Jun 7 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 American Chemical Society.

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.9b01520

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abstract = "An NHC-catalyzed α-carbon amination of chloroaldehydes was developed. Cyclohexadiene-1,2-diimines are used as amination reagents and four-atom synthons. Our reaction affords optically enriched dihydroquinoxalines that are core structures in natural products and synthetic bioactive molecules.",

author = "Ruoyan Huang and Xingkuan Chen and Chengli Mou and Guoyong Luo and Yongjia Li and Xiangyang Li and Wei Xue and Zhichao Jin and Chi, \{Yonggui Robin\}",

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doi = "10.1021/acs.orglett.9b01520",

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T1 - Carbene-Catalyzed α-Carbon Amination of Chloroaldehydes for Enantioselective Access to Dihydroquinoxaline Derivatives

AU - Huang, Ruoyan

AU - Chen, Xingkuan

AU - Mou, Chengli

AU - Luo, Guoyong

AU - Li, Yongjia

AU - Li, Xiangyang

AU - Xue, Wei

AU - Jin, Zhichao

AU - Chi, Yonggui Robin

PY - 2019/6/7

Y1 - 2019/6/7

N2 - An NHC-catalyzed α-carbon amination of chloroaldehydes was developed. Cyclohexadiene-1,2-diimines are used as amination reagents and four-atom synthons. Our reaction affords optically enriched dihydroquinoxalines that are core structures in natural products and synthetic bioactive molecules.

AB - An NHC-catalyzed α-carbon amination of chloroaldehydes was developed. Cyclohexadiene-1,2-diimines are used as amination reagents and four-atom synthons. Our reaction affords optically enriched dihydroquinoxalines that are core structures in natural products and synthetic bioactive molecules.

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Carbene-Catalyzed α-Carbon Amination of Chloroaldehydes for Enantioselective Access to Dihydroquinoxaline Derivatives

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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