Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters

Xingkuan Chen, Jacqueline Zi Mei Fong, Jianfeng Xu, Chengli Mou, Yunpeng Lu, Song Yang, Bao An Song, Yonggui Robin Chi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)

Abstract

Carbene-catalyzed reaction of carboxylic esters has the potential to offer effective synthetic solutions that cannot be readily achieved by using the more conventional aldehyde-Type substrates. Here we report the first carbene-catalyzed dynamic kinetic resolution of α,α-disubstituted carboxylic esters with up to 99:1 er and 99% yield. The present study clearly illustrates the unique power of carbene-catalyzed reactions of readily available and easy to handle carboxylic esters.

Original languageEnglish
Pages (from-to)7212-7215
Number of pages4
JournalJournal of the American Chemical Society
Volume138
Issue number23
DOIs
Publication statusPublished - Jun 15 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 American Chemical Society.

ASJC Scopus Subject Areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry

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