Abstract
Carbene-catalyzed reaction of carboxylic esters has the potential to offer effective synthetic solutions that cannot be readily achieved by using the more conventional aldehyde-Type substrates. Here we report the first carbene-catalyzed dynamic kinetic resolution of α,α-disubstituted carboxylic esters with up to 99:1 er and 99% yield. The present study clearly illustrates the unique power of carbene-catalyzed reactions of readily available and easy to handle carboxylic esters.
Original language | English |
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Pages (from-to) | 7212-7215 |
Number of pages | 4 |
Journal | Journal of the American Chemical Society |
Volume | 138 |
Issue number | 23 |
DOIs | |
Publication status | Published - Jun 15 2016 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2016 American Chemical Society.
ASJC Scopus Subject Areas
- Catalysis
- General Chemistry
- Biochemistry
- Colloid and Surface Chemistry