Carboxylated Chalcone and Benzaldehyde Derivatives of Triosmium Carbonyl Clusters: Synthesis, Characterization and Biological Activity Towards MCF-7 Cells

Zheng Hua Kwek; Rakesh Ganguly; A. Mohamed Afreen; Wei Xiang Koh; Weng Kee Leong; Yong Leng Kelvin Tan

doi:10.1007/s10876-019-01684-8

Carboxylated Chalcone and Benzaldehyde Derivatives of Triosmium Carbonyl Clusters: Synthesis, Characterization and Biological Activity Towards MCF-7 Cells

Zheng Hua Kwek, Rakesh Ganguly, A. Mohamed Afreen, Wei Xiang Koh, Weng Kee Leong, Yong Leng Kelvin Tan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The activated cluster Os₃(CO)₁₀(CH₃CN)₂ (1) reacts readily with a number of carboxylated chalcones and benzaldehydes (2a−j) to afford products with the general formula Os₃(CO)₁₀(µ-H)(µ-O₂CR) (3a–j). The structures of all the novel clusters have been characterized by IR and ¹H NMR spectroscopy, as well as mass spectrometry and elemental analysis. Single-crystal X-ray diffraction analysis has also been carried out for one of the carboxylated chalcones and two of the derivatized clusters. The activity of some of the derivatized clusters against the ER+ breast carcinoma MCF-7 cancer cell line has also been evaluated.

Original language	English
Pages (from-to)	759-767
Number of pages	9
Journal	Journal of Cluster Science
Volume	31
Issue number	4
DOIs	https://doi.org/10.1007/s10876-019-01684-8
Publication status	Published - Jul 1 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.

ASJC Scopus Subject Areas

General Chemistry
Biochemistry
General Materials Science
Condensed Matter Physics

Keywords

Benzaldehyde
Carboxylato
Chalcone
Ferrocene
Osmium cluster

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10876-019-01684-8

Cite this

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title = "Carboxylated Chalcone and Benzaldehyde Derivatives of Triosmium Carbonyl Clusters: Synthesis, Characterization and Biological Activity Towards MCF-7 Cells",

abstract = "The activated cluster Os3(CO)10(CH3CN)2 (1) reacts readily with a number of carboxylated chalcones and benzaldehydes (2a−j) to afford products with the general formula Os3(CO)10(µ-H)(µ-O2CR) (3a–j). The structures of all the novel clusters have been characterized by IR and 1H NMR spectroscopy, as well as mass spectrometry and elemental analysis. Single-crystal X-ray diffraction analysis has also been carried out for one of the carboxylated chalcones and two of the derivatized clusters. The activity of some of the derivatized clusters against the ER+ breast carcinoma MCF-7 cancer cell line has also been evaluated.",

keywords = "Benzaldehyde, Carboxylato, Chalcone, Ferrocene, Osmium cluster",

author = "Kwek, {Zheng Hua} and Rakesh Ganguly and Afreen, {A. Mohamed} and Koh, {Wei Xiang} and Leong, {Weng Kee} and Tan, {Yong Leng Kelvin}",

note = "Publisher Copyright: {\textcopyright} 2019, Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2020",

month = jul,

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doi = "10.1007/s10876-019-01684-8",

language = "English",

volume = "31",

pages = "759--767",

journal = "Journal of Cluster Science",

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TY - JOUR

T1 - Carboxylated Chalcone and Benzaldehyde Derivatives of Triosmium Carbonyl Clusters

T2 - Synthesis, Characterization and Biological Activity Towards MCF-7 Cells

AU - Kwek, Zheng Hua

AU - Ganguly, Rakesh

AU - Afreen, A. Mohamed

AU - Koh, Wei Xiang

AU - Leong, Weng Kee

AU - Tan, Yong Leng Kelvin

PY - 2020/7/1

Y1 - 2020/7/1

N2 - The activated cluster Os3(CO)10(CH3CN)2 (1) reacts readily with a number of carboxylated chalcones and benzaldehydes (2a−j) to afford products with the general formula Os3(CO)10(µ-H)(µ-O2CR) (3a–j). The structures of all the novel clusters have been characterized by IR and 1H NMR spectroscopy, as well as mass spectrometry and elemental analysis. Single-crystal X-ray diffraction analysis has also been carried out for one of the carboxylated chalcones and two of the derivatized clusters. The activity of some of the derivatized clusters against the ER+ breast carcinoma MCF-7 cancer cell line has also been evaluated.

AB - The activated cluster Os3(CO)10(CH3CN)2 (1) reacts readily with a number of carboxylated chalcones and benzaldehydes (2a−j) to afford products with the general formula Os3(CO)10(µ-H)(µ-O2CR) (3a–j). The structures of all the novel clusters have been characterized by IR and 1H NMR spectroscopy, as well as mass spectrometry and elemental analysis. Single-crystal X-ray diffraction analysis has also been carried out for one of the carboxylated chalcones and two of the derivatized clusters. The activity of some of the derivatized clusters against the ER+ breast carcinoma MCF-7 cancer cell line has also been evaluated.

KW - Benzaldehyde

KW - Carboxylato

KW - Chalcone

KW - Ferrocene

KW - Osmium cluster

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U2 - 10.1007/s10876-019-01684-8

DO - 10.1007/s10876-019-01684-8

M3 - Article

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SN - 1040-7278

VL - 31

SP - 759

EP - 767

JO - Journal of Cluster Science

JF - Journal of Cluster Science

IS - 4

ER -

Carboxylated Chalcone and Benzaldehyde Derivatives of Triosmium Carbonyl Clusters: Synthesis, Characterization and Biological Activity Towards MCF-7 Cells

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

UN SDGs

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